An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulfide cross-linking and homology modeling.
The multidrug resistance P-glycoprotein mediates the extrusion of chemotherapeutic drugs from cancer cells. Characterization of the drug binding and ATPase activities of the protein have made it the paradigm ATP binding cassette (ABC) transporter. P-glycoprotein has been imaged at low resolution by...
Autors principals: | Stenham, DR, Campbell, J, Sansom, MS, Higgins, C, Kerr, I, Linton, K |
---|---|
Format: | Journal article |
Idioma: | English |
Publicat: |
2003
|
Ítems similars
-
Structure and association of ATP-binding cassette transporter nucleotide-binding domains
per: Kerr, I
Publicat: (2002) -
Membrane-assisted tariquidar access and binding mechanisms of human ATP-binding cassette transporter P-glycoprotein
per: Yingjie Gao, et al.
Publicat: (2024-03-01) -
The ABC transporters of human physiology and disease : genetics and biochemistry of ATP binding cassette transporters /
per: Linton, Kenneth J., et al.
Publicat: (2011) -
Human ATP-binding cassette (ABC) transporter family
per: Vasiliou Vasilis, et al.
Publicat: (2009-04-01) -
The human ATP-binding cassette (ABC) transporter superfamily
per: Michael Dean, et al.
Publicat: (2001-07-01)