An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulfide cross-linking and homology modeling.

An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulfide cross-linking and homology modeling.

The multidrug resistance P-glycoprotein mediates the extrusion of chemotherapeutic drugs from cancer cells. Characterization of the drug binding and ATPase activities of the protein have made it the paradigm ATP binding cassette (ABC) transporter. P-glycoprotein has been imaged at low resolution by...

Full description

Bibliographic Details
Main Authors:	Stenham, DR, Campbell, J, Sansom, MS, Higgins, C, Kerr, I, Linton, K
Format:	Journal article
Language:	English
Published:	2003

Similar Items

Structure and association of ATP-binding cassette transporter nucleotide-binding domains
by: Kerr, I
Published: (2002)

Membrane-assisted tariquidar access and binding mechanisms of human ATP-binding cassette transporter P-glycoprotein
by: Yingjie Gao, et al.
Published: (2024-03-01)

The ABC transporters of human physiology and disease : genetics and biochemistry of ATP binding cassette transporters /
by: Linton, Kenneth J., et al.
Published: (2011)

Human ATP-binding cassette (ABC) transporter family
by: Vasiliou Vasilis, et al.
Published: (2009-04-01)

The human ATP-binding cassette (ABC) transporter superfamily
by: Michael Dean, et al.
Published: (2001-07-01)

ATP binding cassette systems: structures, mechanisms, and functions
by: Licht Anke, et al.
Published: (2011-10-01)

The impact of ATP-binding cassette transporters on metabolic diseases
by: Zixiang Ye, et al.
Published: (2020-08-01)

The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis.
by: Christopher Kay, et al.
Published: (2012-01-01)

Ribosome protection by antibiotic resistance ATP-binding cassette protein
by: Su, Weixin, et al.
Published: (2020)

ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis
by: Marina B.R. de Santana, et al.
Published: (2025-02-01)

The Role of ATP-Binding Cassette Proteins in Stem Cell Pluripotency
by: Prince Saini, et al.
Published: (2023-06-01)

ATP-binding cassette systems in <it>Burkholderia pseudomallei </it>and <it>Burkholderia mallei</it>
by: Titball Richard W, et al.
Published: (2007-03-01)

ATP-binding cassette (ABC) transporters in normal and pathological lung
by: Timmer-Bosscha Hetty, et al.
Published: (2005-06-01)

Atomic Detail Studies of P-Glycoprotein and Drug Permeation in Model Membranes
by: Ma, J, et al.
Published: (2012)

Partial characterisation of ATP-binding cassette encoding genes in Cryptosporidium parvum
by: Chan, Li Li, et al.
Published: (2004)

Genome-wide analysis of ATP binding cassette (ABC) transporters in tomato.
by: Peter Amoako Ofori, et al.
Published: (2018-01-01)

The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease
by: Asli Aykac, et al.
Published: (2021-09-01)

Mass Spectrometry Investigation of Some ATP-Binding Cassette (ABC) Proteins
by: Marco Agostini, et al.
Published: (2024-01-01)

Expression of some ATP-binding cassette transporters in acute myeloid leukemia
by: Antonella Maria Salvia, et al.
Published: (2017-12-01)

The role of ATP-binding cassette subfamily A in the etiology of Alzheimer’s disease
by: Liene Bossaerts, et al.
Published: (2022-04-01)

ATP-binding cassette transporter A1: From metabolism to neurodegeneration
by: Radosveta Koldamova, et al.
Published: (2014-12-01)

ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species
by: Monique Budani, et al.
Published: (2021-01-01)

Predicting ATP-Binding Cassette Transporters Using the Random Forest Method
by: Ruiyan Hou, et al.
Published: (2020-03-01)

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
by: Shintre, C, et al.
Published: (2013)

Partial characterization of genes encoding the ATP-binding cassette proteins of Cryptosporidium parvum
by: Chan, L.L., et al.
Published: (2005)

Functional significance of the ATP‐binding cassette transporter B6 in hepatocellular carcinoma
by: Kishore Polireddy, et al.
Published: (2011-10-01)

The role of ATP-binding Cassette subfamily B member 6 in the inner ear
by: Stefanie A. Baril, et al.
Published: (2024-11-01)

Aging Reduces ATP-Binding Cassette Transporter Expression in Brain Microvessels of Mice
by: Yukiyo Wada, et al.
Published: (2025-01-01)

The B subfamily of plant ATP binding cassette transporters and their roles in auxin transport
by: Y. X. Xu, et al.
Published: (2014-09-01)

The role of ATP‐binding cassette subfamily G member 1 in tumor progression
by: Xu Xinyi, et al.
Published: (2024-06-01)

Cardiac PET Imaging of ATP Binding Cassette (ABC) Transporters: Opportunities and Challenges
by: Wanling Liu, et al.
Published: (2023-12-01)

Identification and Characterization of ATP-Binding Cassette Transporters in <i>Chlamydomonas reinhardtii</i>
by: Xiangyu Li, et al.
Published: (2022-09-01)

The Methods to Overcome ATP-binding Cassette Transporters-mediated Multi-drug Resistance
by: Mansoureh Entezar-e-Ghaem, et al.
Published: (2013-01-01)

Beauvericin potentiates the activity of pesticides by neutralizing the ATP-binding cassette transporters in arthropods
by: Charbel Al Khoury, et al.
Published: (2021-05-01)

The pharmacological impact of ATP-binding cassette drug transporters on vemurafenib-based therapy
by: Chung-Pu Wu, et al.
Published: (2014-04-01)

ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches
by: Ahmad Elbahnsi, et al.
Published: (2024-11-01)

Increased expression of ATP‐binding cassette transporters in enfortumab vedotin‐resistant urothelial cancer
by: Mariko Kotono, et al.
Published: (2024-03-01)

Identification and Expression Characterization of ATP-Binding Cassette (ABC) Transporter Genes in Melon Fly
by: Hui-Qian Xu, et al.
Published: (2021-03-01)

Function and Role of ATP-Binding Cassette Transporters as Receptors for 3D-Cry Toxins
by: Ryoichi Sato, et al.
Published: (2019-02-01)

Functional analysis of the ATP-binding cassette (ABC) transporter gene family of <it>Tribolium castaneum</it>
by: Broehan Gunnar, et al.
Published: (2013-01-01)