Cryptococcal meningitis: a neglected NTD?

Although HIV/AIDS has been anything but neglected over the last decade, opportunistic infections (OIs) are increasingly overlooked as large scale donors shift their focus from acute care to prevention and earlier antiretroviral treatment (ART) initiation. Of these OIs, cryptococcal meningitis, a de...

Full description

Bibliographic Details
Main Authors: Molloy, S, Chiller, T, Greene, G, Burry, J, Day, J, Govender, N, Kanyama, C, Mfinanga, S, Boulware, D, Dromer, F, Denning, D, Mapoure, Y, Stone, N, Bicanic, T, Jarvis, J, Lortholary, O, Harrison, T, Jaffar, S, Loyse, A
Format: Journal article
Published: Public Library of Science 2017
Description
Summary:Although HIV/AIDS has been anything but neglected over the last decade, opportunistic infections (OIs) are increasingly overlooked as large scale donors shift their focus from acute care to prevention and earlier antiretroviral treatment (ART) initiation. Of these OIs, cryptococcal meningitis, a deadly invasive fungal infection, continues to affect hundreds of thousands of HIV patients with advanced disease each year and is responsible for an estimated 15%-20% of all AIDS-related deaths [1,2]. Yet cryptococcal meningitis ranks amongst the most poorly funded “neglected” diseases in the world, receiving 0.2% of available relevant research and development (R&D;) funding according to Policy Cures’ 2016 G-Finder Report [3,4].