The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy.
1 The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes are described. 2 Only one class of binding site can be demonstrated. Binding is time- and temperature-dependent, saturable and slowly reversible; it is inhibited by other cardiac glycosides an...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1979
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| _version_ | 1797083647877054464 |
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| author | Ford, A Aronson, J Grahame-Smith, D Rose, J |
| author_facet | Ford, A Aronson, J Grahame-Smith, D Rose, J |
| author_sort | Ford, A |
| collection | OXFORD |
| description | 1 The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes are described. 2 Only one class of binding site can be demonstrated. Binding is time- and temperature-dependent, saturable and slowly reversible; it is inhibited by other cardiac glycosides and by potassium. 3 Pre-incubation with unlabelled digoxin reduces the subsequent binding of 12-alpha-[3H]-digoxin in stoichiometric fashion. 4 The possible application of the measurement of the binding of 12-alpha-[3H]-digoxin to the study of biochemical pharmacological events occurring during digoxin therapy is discussed. |
| first_indexed | 2024-03-07T01:44:24Z |
| format | Journal article |
| id | oxford-uuid:97eeb50d-f05d-4e5a-b4b3-e383ef756101 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:44:24Z |
| publishDate | 1979 |
| record_format | dspace |
| spelling | oxford-uuid:97eeb50d-f05d-4e5a-b4b3-e383ef7561012022-03-27T00:03:20ZThe characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:97eeb50d-f05d-4e5a-b4b3-e383ef756101EnglishSymplectic Elements at Oxford1979Ford, AAronson, JGrahame-Smith, DRose, J1 The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes are described. 2 Only one class of binding site can be demonstrated. Binding is time- and temperature-dependent, saturable and slowly reversible; it is inhibited by other cardiac glycosides and by potassium. 3 Pre-incubation with unlabelled digoxin reduces the subsequent binding of 12-alpha-[3H]-digoxin in stoichiometric fashion. 4 The possible application of the measurement of the binding of 12-alpha-[3H]-digoxin to the study of biochemical pharmacological events occurring during digoxin therapy is discussed. |
| spellingShingle | Ford, A Aronson, J Grahame-Smith, D Rose, J The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy. |
| title | The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy. |
| title_full | The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy. |
| title_fullStr | The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy. |
| title_full_unstemmed | The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy. |
| title_short | The characteristics of the binding of 12-alpha-[3H]-digoxin to the membranes of intact human erythrocytes: relevance to digoxin therapy. |
| title_sort | characteristics of the binding of 12 alpha 3h digoxin to the membranes of intact human erythrocytes relevance to digoxin therapy |
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