Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases.
The reaction of enol(ate)s with electrophiles is used extensively in organic synthesis for stereoselective C-C bond formation. Protein-based catalysts have had comparatively limited application for the stereoselective formation of C-C bonds of choice via enolate chemistry. We describe protein engine...
المؤلفون الرئيسيون: | Hamed, R, Gomez-Castellanos, JR, Thalhammer, A, Harding, D, Ducho, C, Claridge, T, Schofield, C |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2011
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مواد مشابهة
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Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.
حسب: Hamed, R, وآخرون
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Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily.
حسب: Batchelar, E, وآخرون
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Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.
حسب: Hamed, R, وآخرون
منشور في: (2009) -
Engineering carboxymethylproline synthases towards the biosynthetic productions of carbapenem antibiotics
حسب: Gómez Castellanos, J
منشور في: (2013) -
Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis.
حسب: Sleeman, M, وآخرون
منشور في: (2004)