CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner.
CD161(++) CD8(+) T cells represent a novel subset that is dominated in adult peripheral blood by mucosal-associated invariant T (MAIT) cells, as defined by the expression of a variable-α chain 7.2 (Vα7.2)-Jα33 TCR, and IL-18Rα. Stimulation with IL-18+IL-12 is known to induce IFN-γ by both NK cells a...
| मुख्य लेखकों: | , , , , , , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2014
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| _version_ | 1826286513076305920 |
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| author | Ussher, J Bilton, M Attwod, E Shadwell, J Richardson, R de Lara, C Mettke, E Kurioka, A Hansen, T Klenerman, P Willberg, C |
| author_facet | Ussher, J Bilton, M Attwod, E Shadwell, J Richardson, R de Lara, C Mettke, E Kurioka, A Hansen, T Klenerman, P Willberg, C |
| author_sort | Ussher, J |
| collection | OXFORD |
| description | CD161(++) CD8(+) T cells represent a novel subset that is dominated in adult peripheral blood by mucosal-associated invariant T (MAIT) cells, as defined by the expression of a variable-α chain 7.2 (Vα7.2)-Jα33 TCR, and IL-18Rα. Stimulation with IL-18+IL-12 is known to induce IFN-γ by both NK cells and, to a more limited extent, T cells. Here, we show the CD161(++) CD8(+) T-cell population is the primary T-cell population triggered by this mechanism. Both CD161(++) Vα7.2(+) and CD161(++) Vα7.2(-) T-cell subsets responded to IL-12+IL-18 stimulation, demonstrating this response was not restricted to the MAIT cells, but to the CD161(++) phenotype. Bacteria and TLR agonists also indirectly triggered IFN-γ expression via IL-12 and IL-18. These data show that CD161(++) T cells are the predominant T-cell population that responds directly to IL-12+IL-18 stimulation. Furthermore, our findings broaden the potential role of MAIT cells beyond bacterial responsiveness to potentially include viral infections and other inflammatory stimuli. |
| first_indexed | 2024-03-07T01:44:53Z |
| format | Journal article |
| id | oxford-uuid:9812d79e-a016-4fcf-a155-61f353d81ece |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:44:53Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:9812d79e-a016-4fcf-a155-61f353d81ece2022-03-27T00:04:26ZCD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9812d79e-a016-4fcf-a155-61f353d81eceEnglishSymplectic Elements at Oxford2014Ussher, JBilton, MAttwod, EShadwell, JRichardson, Rde Lara, CMettke, EKurioka, AHansen, TKlenerman, PWillberg, CCD161(++) CD8(+) T cells represent a novel subset that is dominated in adult peripheral blood by mucosal-associated invariant T (MAIT) cells, as defined by the expression of a variable-α chain 7.2 (Vα7.2)-Jα33 TCR, and IL-18Rα. Stimulation with IL-18+IL-12 is known to induce IFN-γ by both NK cells and, to a more limited extent, T cells. Here, we show the CD161(++) CD8(+) T-cell population is the primary T-cell population triggered by this mechanism. Both CD161(++) Vα7.2(+) and CD161(++) Vα7.2(-) T-cell subsets responded to IL-12+IL-18 stimulation, demonstrating this response was not restricted to the MAIT cells, but to the CD161(++) phenotype. Bacteria and TLR agonists also indirectly triggered IFN-γ expression via IL-12 and IL-18. These data show that CD161(++) T cells are the predominant T-cell population that responds directly to IL-12+IL-18 stimulation. Furthermore, our findings broaden the potential role of MAIT cells beyond bacterial responsiveness to potentially include viral infections and other inflammatory stimuli. |
| spellingShingle | Ussher, J Bilton, M Attwod, E Shadwell, J Richardson, R de Lara, C Mettke, E Kurioka, A Hansen, T Klenerman, P Willberg, C CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. |
| title | CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. |
| title_full | CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. |
| title_fullStr | CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. |
| title_full_unstemmed | CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. |
| title_short | CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. |
| title_sort | cd161 cd8 t cells including the mait cell subset are specifically activated by il 12 il 18 in a tcr independent manner |
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