CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner.

CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner.

CD161(++) CD8(+) T cells represent a novel subset that is dominated in adult peripheral blood by mucosal-associated invariant T (MAIT) cells, as defined by the expression of a variable-α chain 7.2 (Vα7.2)-Jα33 TCR, and IL-18Rα. Stimulation with IL-18+IL-12 is known to induce IFN-γ by both NK cells a...

书目详细资料
Main Authors:	Ussher, J, Bilton, M, Attwod, E, Shadwell, J, Richardson, R, de Lara, C, Mettke, E, Kurioka, A, Hansen, T, Klenerman, P, Willberg, C
格式:	Journal article
语言:	English
出版:	2014

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