Phenotypic variation modulates the growth dynamics and response to radiotherapy of solid tumours under normoxia and hypoxia.

Phenotypic variation modulates the growth dynamics and response to radiotherapy of solid tumours under normoxia and hypoxia.

In cancer, treatment failure and disease recurrence have been associated with small subpopulations of cancer cells with a stem-like phenotype. In this paper, we develop and investigate a phenotype-structured model of solid tumour growth in which cells are structured by a stemness level, which varies...

Полное описание

Библиографические подробности
Главные авторы:	Celora, GL, Byrne, HM, Zois, CE, Kevrekidis, PG
Формат:	Journal article
Язык:	English
Опубликовано:	Elsevier 2021

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