Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells.

Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells.

In humans, polyadenylation of messenger RNA (mRNA) protects transcripts from degradation and enhances translation efficiency. Conversely, in bacteria, polyadenylation destabilizes mRNA. RNA adenylation was recently implicated in promoting degradation of some yeast RNAs by the exosome. The exosome co...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	West, S, Gromak, N, Norbury, C, Proudfoot, N
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2006

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Modulating alternative splicing by cotranscriptional cleavage of nascent intronic RNA.
gan: Gromak, N, et al.
Cyhoeddwyd: (2008)

Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase II.
gan: Dye, M, et al.
Cyhoeddwyd: (1999)

20 years of making messenger RNA.
gan: Proudfoot, N
Cyhoeddwyd: (1997)

Observation of coordinated RNA folding events by systematic cotranscriptional RNA structure probing
gan: Courtney E. Szyjka, et al.
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Kinetic analysis demonstrates a requirement for the Rat1 exonuclease in cotranscriptional pre-rRNA cleavage.
gan: Konstantin Axt, et al.
Cyhoeddwyd: (2014-01-01)

Messenger RNAs that are not synthesized by RNA polymerase II can be 3' end cleaved and polyadenylated.
gan: Fodor, E, et al.
Cyhoeddwyd: (2000)

Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing
gan: Elena A. Matveeva, et al.
Cyhoeddwyd: (2019-02-01)

Nucleotide sequences of globin messenger RNA.
gan: Proudfoot, N, et al.
Cyhoeddwyd: (1976)

Pause sites promote transcriptional termination of mammalian RNA polymerase II.
gan: Gromak, N, et al.
Cyhoeddwyd: (2006)

The 3' terminal sequences of human alpha and beta globin messenger RNAs: comparison with rabbit globin messenger RNA.
gan: Proudfoot, N, et al.
Cyhoeddwyd: (1976)

Nucleotide sequence of the 3' terminal third of rabbit alpha-globin messenger RNA: comparison with human alpha-globin messenger RNA.
gan: Proudfoot, N, et al.
Cyhoeddwyd: (1977)

GLOBIN GENES AND MESSENGER-RNA FROM HUMANS WITH THALASSEMIA
gan: Proudfoot, N, et al.
Cyhoeddwyd: (1979)

3' non-coding region sequences in eukaryotic messenger RNA.
gan: Proudfoot, N, et al.
Cyhoeddwyd: (1976)

Cotranscription and intergenic splicing of the <it>PPARG </it>and <it>TSEN2 </it>genes in cattle
gan: Amarger Valérie, et al.
Cyhoeddwyd: (2006-04-01)

Cotranscriptional and Posttranscriptional Features of the Transcriptome in Soybean Shoot Apex and Leaf
gan: Jiafu Zhu, et al.
Cyhoeddwyd: (2021-04-01)

Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes
gan: Kim Sneppen, et al.
Cyhoeddwyd: (2010-10-01)

Nucleotide sequence from the coding region of rabbit beta-globin messenger RNA.
gan: Proudfoot, N
Cyhoeddwyd: (1976)

Colored petri net modeling of small interfering RNA-mediated messenger RNA degradation
gan: Niloofar Nickaeen, et al.
Cyhoeddwyd: (2016-01-01)

Genome-wide probing of eukaryotic nascent RNA structure elucidates cotranscriptional folding and its antimutagenic effect
gan: Gongwang Yu, et al.
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The conserved RNA-binding protein Seb1 promotes cotranscriptional ribosomal RNA processing by controlling RNA polymerase I progression
gan: Maxime Duval, et al.
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Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination.
gan: West, S, et al.
Cyhoeddwyd: (2008)

Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination
gan: West, S, et al.
Cyhoeddwyd: (2008)

Turnover and function of noncoding RNA polymerase II transcripts.
gan: Dye, M, et al.
Cyhoeddwyd: (2006)

Sequence analysis of immunoglobulin light chain messenger RNA.
gan: Milstein, C, et al.
Cyhoeddwyd: (1974)

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.
gan: West, S, et al.
Cyhoeddwyd: (2004)

Coupling termination of transcription to messenger RNA maturation in yeast.
gan: Birse, C, et al.
Cyhoeddwyd: (1998)

Single-molecule FRET studies on the cotranscriptional folding of a thiamine pyrophosphate riboswitch
gan: Uhm, H, et al.
Cyhoeddwyd: (2017)

Cis-cotranscription of two beta globin genes during chicken primitive hematopoiesis.
gan: Hiroki Nagai, et al.
Cyhoeddwyd: (2007-01-01)

Cotranslational microRNA mediated messenger RNA destabilization
gan: Trinh To Tat, et al.
Cyhoeddwyd: (2016-04-01)

CHARACTERIZATION OF BETA-GLOBIN MESSENGER-RNA IN BETA-O THALASSEMIAS
gan: Old, J, et al.
Cyhoeddwyd: (1978)

Exon tethering in transcription by RNA polymerase II.
gan: Dye, M, et al.
Cyhoeddwyd: (2006)

IDENTIFICATION OF 3 DIFFERENT TYPES OF BETA-THALASSEMIA BY MESSENGER-RNA ANALYSIS
gan: Old, J, et al.
Cyhoeddwyd: (1978)

Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
gan: Skourti-Stathaki, K, et al.
Cyhoeddwyd: (2011)

Crystal structure of an RNA-cleaving DNAzyme
gan: Hehua Liu, et al.
Cyhoeddwyd: (2017-12-01)

Complete 3' noncoding region sequences of rabbit and human beta-globin messenger RNAs.
gan: Proudfoot, N
Cyhoeddwyd: (1977)

SEQUENCE AT 3' END OF GLOBIN MESSENGER-RNA SHOWS HOMOLOGY WITH IMMUNOGLOBULIN LIGHT CHAIN MESSENGER-RNA
gan: Proudfoo, N, et al.
Cyhoeddwyd: (1974)

Insights into the cotranscriptional and translational control mechanisms of the Escherichia coli tbpA thiamin pyrophosphate riboswitch
gan: Jonathan P. Grondin, et al.
Cyhoeddwyd: (2024-10-01)

Tear exosomes: A messenger of clinical health complication
gan: Divya Mirgh, et al.
Cyhoeddwyd: (2023-12-01)

Small but Mighty—Exosomes, Novel Intercellular Messengers in Neurodegeneration
gan: Meena Kumari, et al.
Cyhoeddwyd: (2022-03-01)

Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
gan: Anshul S. Jadli, et al.
Cyhoeddwyd: (2021-11-01)