Dietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort.
We prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires we...
| Үндсэн зохиолчид: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Формат: | Journal article |
| Хэл сонгох: | English |
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2013
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| _version_ | 1826286562491498496 |
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| author | Vermeulen, E Zamora-Ros, R Duell, E Luján-Barroso, L Boeing, H Aleksandrova, K Bueno-de-Mesquita, H Scalbert, A Romieu, I Fedirko, V Touillaud, M Fagherazzi, G Perquier, F Molina-Montes, E Chirlaque, MD Vicente Argüelles, M Amiano, P Barricarte, A Pala, V Mattiello, A Saieva, C Tumino, R Ricceri, F Trichopoulou, A Vasilopoulou, E |
| author_facet | Vermeulen, E Zamora-Ros, R Duell, E Luján-Barroso, L Boeing, H Aleksandrova, K Bueno-de-Mesquita, H Scalbert, A Romieu, I Fedirko, V Touillaud, M Fagherazzi, G Perquier, F Molina-Montes, E Chirlaque, MD Vicente Argüelles, M Amiano, P Barricarte, A Pala, V Mattiello, A Saieva, C Tumino, R Ricceri, F Trichopoulou, A Vasilopoulou, E |
| author_sort | Vermeulen, E |
| collection | OXFORD |
| description | We prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires were used. During a mean follow-up of 11 years (1992-2010), there were 341 incident esophageal cancer cases, of which 142 were esophageal adenocarcinoma (EAC), 176 were esophageal squamous cell carcinoma (ESCC), and 23 were other types of esophageal cancer. In crude models, a doubling in total dietary flavonoid intake was inversely associated with esophageal cancer risk (hazard ratio (HR) (log₂) = 0.87, 95% confidence interval (CI): 0.78, 0.98) but not in multivariable models (HR (log₂) = 0.97, 95% CI: 0.86, 1.10). After covariate adjustment, no statistically significant association was found between any flavonoid subclass and esophageal cancer, EAC, or ESCC. However, among current smokers, flavonols were statistically significantly associated with a reduced esophageal cancer risk (HR (log₂) = 0.72, 95% CI: 0.56, 0.94), whereas total flavonoids, flavanols, and flavan-3-ol monomers tended to be inversely associated with esophageal cancer risk. No associations were found in either never or former smokers. These findings suggest that dietary flavonoid intake was not associated with overall esophageal cancer, EAC, or ESCC risk, although total flavonoids and some flavonoid subclasses, particularly flavonols, may reduce the esophageal cancer risk among current smokers. |
| first_indexed | 2024-03-07T01:45:36Z |
| format | Journal article |
| id | oxford-uuid:98528ac7-4cb0-4dba-a8c1-c06dfca32d3c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:45:36Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:98528ac7-4cb0-4dba-a8c1-c06dfca32d3c2022-03-27T00:06:06ZDietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:98528ac7-4cb0-4dba-a8c1-c06dfca32d3cEnglishSymplectic Elements at Oxford2013Vermeulen, EZamora-Ros, RDuell, ELuján-Barroso, LBoeing, HAleksandrova, KBueno-de-Mesquita, HScalbert, ARomieu, IFedirko, VTouillaud, MFagherazzi, GPerquier, FMolina-Montes, EChirlaque, MDVicente Argüelles, MAmiano, PBarricarte, APala, VMattiello, ASaieva, CTumino, RRicceri, FTrichopoulou, AVasilopoulou, EWe prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires were used. During a mean follow-up of 11 years (1992-2010), there were 341 incident esophageal cancer cases, of which 142 were esophageal adenocarcinoma (EAC), 176 were esophageal squamous cell carcinoma (ESCC), and 23 were other types of esophageal cancer. In crude models, a doubling in total dietary flavonoid intake was inversely associated with esophageal cancer risk (hazard ratio (HR) (log₂) = 0.87, 95% confidence interval (CI): 0.78, 0.98) but not in multivariable models (HR (log₂) = 0.97, 95% CI: 0.86, 1.10). After covariate adjustment, no statistically significant association was found between any flavonoid subclass and esophageal cancer, EAC, or ESCC. However, among current smokers, flavonols were statistically significantly associated with a reduced esophageal cancer risk (HR (log₂) = 0.72, 95% CI: 0.56, 0.94), whereas total flavonoids, flavanols, and flavan-3-ol monomers tended to be inversely associated with esophageal cancer risk. No associations were found in either never or former smokers. These findings suggest that dietary flavonoid intake was not associated with overall esophageal cancer, EAC, or ESCC risk, although total flavonoids and some flavonoid subclasses, particularly flavonols, may reduce the esophageal cancer risk among current smokers. |
| spellingShingle | Vermeulen, E Zamora-Ros, R Duell, E Luján-Barroso, L Boeing, H Aleksandrova, K Bueno-de-Mesquita, H Scalbert, A Romieu, I Fedirko, V Touillaud, M Fagherazzi, G Perquier, F Molina-Montes, E Chirlaque, MD Vicente Argüelles, M Amiano, P Barricarte, A Pala, V Mattiello, A Saieva, C Tumino, R Ricceri, F Trichopoulou, A Vasilopoulou, E Dietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort. |
| title | Dietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort. |
| title_full | Dietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort. |
| title_fullStr | Dietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort. |
| title_full_unstemmed | Dietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort. |
| title_short | Dietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort. |
| title_sort | dietary flavonoid intake and esophageal cancer risk in the european prospective investigation into cancer and nutrition cohort |
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