Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.

Local hypoxia in hematopoietic stem cell (HSC) niches is thought to regulate HSC functions. Hypoxia-inducible factor-1 (Hif-1) and Hif-2 are key mediators of cellular responses to hypoxia. Although oxygen-regulated α-subunits of Hifs, namely Hif-1α and Hif-2α, are closely related, they play overlapp...

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Bibliographic Details
Main Authors:	Guitart, A, Subramani, C, Armesilla-Diaz, A, Smith, G, Sepulveda, C, Gezer, D, Vukovic, M, Dunn, K, Pollard, P, Holyoake, T, Enver, T, Ratcliffe, P, Kranc, K
Format:	Journal article
Language:	English
Published:	2013

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