Biomarkers for severe eosinophilic asthma.
The last decade has seen the approval of several new biologics for the treatment of severe asthma-targeting specific endotypes and phenotypes. This review will examine how evidence generated from the mepolizumab clinical development program showed that blood eosinophil counts, rather than sputum or...
Main Authors: | Yancey, S, Keene, O, Albers, F, Ortega, H, Bates, S, Bleecker, E, Pavord, I |
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Format: | Journal article |
Sprog: | English |
Udgivet: |
Elsevier
2017
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Lignende værker
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Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma
af: Yancey, S, et al.
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Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies.
af: Ortega, H, et al.
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Evaluation of potential continuation rules for mepolizumab treatment of severe eosinophilic asthma.
af: Gunsoy, N, et al.
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Fractional exhaled nitric oxide and the peripheral blood eosinophil count as biomarkers of the response to mepolizumab in patients with severe eosinophilic asthma
af: Shrimanker, R, et al.
Udgivet: (2018) -
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial.
af: Pavord, I, et al.
Udgivet: (2012)