Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease.
BACKGROUND/AIMS: Growth retardation is a recognised complication of paediatric Cushing's disease (CD), but there are few published data on skeletal maturation at diagnosis. We assessed factors contributing to skeletal maturation in patients with paediatric CD. PATIENTS/METHODS: 17 patients, 12...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797083778802253824 |
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| author | Peters, C Ahmed, M Storr, H Davies, K Martin, L Allgrove, J Grossman, AB Savage, M |
| author_facet | Peters, C Ahmed, M Storr, H Davies, K Martin, L Allgrove, J Grossman, AB Savage, M |
| author_sort | Peters, C |
| collection | OXFORD |
| description | BACKGROUND/AIMS: Growth retardation is a recognised complication of paediatric Cushing's disease (CD), but there are few published data on skeletal maturation at diagnosis. We assessed factors contributing to skeletal maturation in patients with paediatric CD. PATIENTS/METHODS: 17 patients, 12 males, 5 females (median age 12.1 years, range 5.8-17.4) were studied. The bone age (BA) of each child was determined by a single observer using the TW3 RUS method. BA delay, i.e. the difference between chronological age (CA) and BA, was compared with clinical and biochemical variables. RESULTS: BA delay was present in 15/17 patients (mean delay 2.0 years, range -0.5 to 4.1 years) and correlated negatively with height SDS (r = -0.70, p < 0.01) and positively with duration of symptoms (r = 0.48, p = 0.05) and CA (r = 0.48, p = 0.05). No relationships were found with midnight cortisol, ACTH, DHEA-S or cortisol suppression during the low-dose dexamethasone suppression test. CONCLUSIONS: BA in most children with CD was delayed and related to length of symptoms and height SDS at diagnosis. Early diagnosis will reduce delay in skeletal maturation and thus contribute to optimal catch-up growth. |
| first_indexed | 2024-03-07T01:46:14Z |
| format | Journal article |
| id | oxford-uuid:9886f662-1fd7-41e1-9c4a-1f6ed0d2e618 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:46:14Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:9886f662-1fd7-41e1-9c4a-1f6ed0d2e6182022-03-27T00:07:31ZFactors influencing skeletal maturation at diagnosis of paediatric Cushing's disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9886f662-1fd7-41e1-9c4a-1f6ed0d2e618EnglishSymplectic Elements at Oxford2007Peters, CAhmed, MStorr, HDavies, KMartin, LAllgrove, JGrossman, ABSavage, MBACKGROUND/AIMS: Growth retardation is a recognised complication of paediatric Cushing's disease (CD), but there are few published data on skeletal maturation at diagnosis. We assessed factors contributing to skeletal maturation in patients with paediatric CD. PATIENTS/METHODS: 17 patients, 12 males, 5 females (median age 12.1 years, range 5.8-17.4) were studied. The bone age (BA) of each child was determined by a single observer using the TW3 RUS method. BA delay, i.e. the difference between chronological age (CA) and BA, was compared with clinical and biochemical variables. RESULTS: BA delay was present in 15/17 patients (mean delay 2.0 years, range -0.5 to 4.1 years) and correlated negatively with height SDS (r = -0.70, p < 0.01) and positively with duration of symptoms (r = 0.48, p = 0.05) and CA (r = 0.48, p = 0.05). No relationships were found with midnight cortisol, ACTH, DHEA-S or cortisol suppression during the low-dose dexamethasone suppression test. CONCLUSIONS: BA in most children with CD was delayed and related to length of symptoms and height SDS at diagnosis. Early diagnosis will reduce delay in skeletal maturation and thus contribute to optimal catch-up growth. |
| spellingShingle | Peters, C Ahmed, M Storr, H Davies, K Martin, L Allgrove, J Grossman, AB Savage, M Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease. |
| title | Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease. |
| title_full | Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease. |
| title_fullStr | Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease. |
| title_full_unstemmed | Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease. |
| title_short | Factors influencing skeletal maturation at diagnosis of paediatric Cushing's disease. |
| title_sort | factors influencing skeletal maturation at diagnosis of paediatric cushing s disease |
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