Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers.
Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2004
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| _version_ | 1826286618547322880 |
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| author | Wertheim, H Vos, M Ott, A van Belkum, A Voss, A Kluytmans, J van Keulen, P Vandenbroucke-Grauls, C Meester, M Verbrugh, H |
| author_facet | Wertheim, H Vos, M Ott, A van Belkum, A Voss, A Kluytmans, J van Keulen, P Vandenbroucke-Grauls, C Meester, M Verbrugh, H |
| author_sort | Wertheim, H |
| collection | OXFORD |
| description | Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1.2%) than in non-carriers (41/10588, 0.4%; relative risk 3.0, 95% CI 2.0-4.7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0.005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0.006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous. |
| first_indexed | 2024-03-07T01:46:25Z |
| format | Journal article |
| id | oxford-uuid:9892d029-7e5a-44f8-9d74-a9144611f0c1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:46:25Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:9892d029-7e5a-44f8-9d74-a9144611f0c12022-03-27T00:07:58ZRisk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9892d029-7e5a-44f8-9d74-a9144611f0c1EnglishSymplectic Elements at Oxford2004Wertheim, HVos, MOtt, Avan Belkum, AVoss, AKluytmans, Jvan Keulen, PVandenbroucke-Grauls, CMeester, MVerbrugh, HStaphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1.2%) than in non-carriers (41/10588, 0.4%; relative risk 3.0, 95% CI 2.0-4.7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0.005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0.006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous. |
| spellingShingle | Wertheim, H Vos, M Ott, A van Belkum, A Voss, A Kluytmans, J van Keulen, P Vandenbroucke-Grauls, C Meester, M Verbrugh, H Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. |
| title | Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. |
| title_full | Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. |
| title_fullStr | Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. |
| title_full_unstemmed | Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. |
| title_short | Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. |
| title_sort | risk and outcome of nosocomial staphylococcus aureus bacteraemia in nasal carriers versus non carriers |
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