Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy.
Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the...
| Príomhchruthaitheoirí: | , , , |
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| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
2002
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| _version_ | 1826286622136598528 |
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| author | van Maurik, A Herber, M Wood, K Jones, N |
| author_facet | van Maurik, A Herber, M Wood, K Jones, N |
| author_sort | van Maurik, A |
| collection | OXFORD |
| description | Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4(+)CD25(+) regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8(+) T cells. |
| first_indexed | 2024-03-07T01:46:28Z |
| format | Journal article |
| id | oxford-uuid:98981a06-3117-4b18-a315-e1b462c01b99 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:46:28Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:98981a06-3117-4b18-a315-e1b462c01b992022-03-27T00:08:07ZCutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:98981a06-3117-4b18-a315-e1b462c01b99EnglishSymplectic Elements at Oxford2002van Maurik, AHerber, MWood, KJones, NBlockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4(+)CD25(+) regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8(+) T cells. |
| spellingShingle | van Maurik, A Herber, M Wood, K Jones, N Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. |
| title | Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. |
| title_full | Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. |
| title_fullStr | Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. |
| title_full_unstemmed | Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. |
| title_short | Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. |
| title_sort | cutting edge cd4 cd25 alloantigen specific immunoregulatory cells that can prevent cd8 t cell mediated graft rejection implications for anti cd154 immunotherapy |
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