Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an importan...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Vilema Enriquez, MG, Quinlan, R, Kilfeather, P, Mazzone, R, Saqlain, S, Del Molino Del Barrio, I, Donato, A, Corda, G, Li, F, Vedadi, M, Németh, AH, Brennan, PE, Wade-Martins, R
التنسيق:	Journal article
اللغة:	English
منشور في:	American Society for Biochemistry and Molecular Biology 2020

مواد مشابهة

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Correction: Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain
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