Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an importan...

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Những tác giả chính:	Vilema Enriquez, MG, Quinlan, R, Kilfeather, P, Mazzone, R, Saqlain, S, Del Molino Del Barrio, I, Donato, A, Corda, G, Li, F, Vedadi, M, Németh, AH, Brennan, PE, Wade-Martins, R
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	American Society for Biochemistry and Molecular Biology 2020

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