A comparative encyclopedia of DNA elements in the mouse genome.
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory progra...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Publishing Group
2014
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| _version_ | 1797083820410798080 |
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| author | Yue, F Cheng, Y Breschi, A Vierstra, J Wu, W Ryba, T Sandstrom, R Ma, Z Davis, C Pope, B Shen, Y Pervouchine, D Djebali, S Thurman, R Kaul, R Rynes, E Kirilusha, A Marinov, G Williams, B Trout, D Amrhein, H Fisher-Aylor, K Antoshechkin, I DeSalvo, G See, L |
| author_facet | Yue, F Cheng, Y Breschi, A Vierstra, J Wu, W Ryba, T Sandstrom, R Ma, Z Davis, C Pope, B Shen, Y Pervouchine, D Djebali, S Thurman, R Kaul, R Rynes, E Kirilusha, A Marinov, G Williams, B Trout, D Amrhein, H Fisher-Aylor, K Antoshechkin, I DeSalvo, G See, L |
| author_sort | Yue, F |
| collection | OXFORD |
| description | The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases. |
| first_indexed | 2024-03-07T01:46:51Z |
| format | Journal article |
| id | oxford-uuid:98b3ab19-214f-4180-9a23-6ea7a6313c8d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:46:51Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:98b3ab19-214f-4180-9a23-6ea7a6313c8d2022-03-27T00:08:56ZA comparative encyclopedia of DNA elements in the mouse genome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:98b3ab19-214f-4180-9a23-6ea7a6313c8dEnglishSymplectic Elements at OxfordNature Publishing Group2014Yue, FCheng, YBreschi, AVierstra, JWu, WRyba, TSandstrom, RMa, ZDavis, CPope, BShen, YPervouchine, DDjebali, SThurman, RKaul, RRynes, EKirilusha, AMarinov, GWilliams, BTrout, DAmrhein, HFisher-Aylor, KAntoshechkin, IDeSalvo, GSee, LThe laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases. |
| spellingShingle | Yue, F Cheng, Y Breschi, A Vierstra, J Wu, W Ryba, T Sandstrom, R Ma, Z Davis, C Pope, B Shen, Y Pervouchine, D Djebali, S Thurman, R Kaul, R Rynes, E Kirilusha, A Marinov, G Williams, B Trout, D Amrhein, H Fisher-Aylor, K Antoshechkin, I DeSalvo, G See, L A comparative encyclopedia of DNA elements in the mouse genome. |
| title | A comparative encyclopedia of DNA elements in the mouse genome. |
| title_full | A comparative encyclopedia of DNA elements in the mouse genome. |
| title_fullStr | A comparative encyclopedia of DNA elements in the mouse genome. |
| title_full_unstemmed | A comparative encyclopedia of DNA elements in the mouse genome. |
| title_short | A comparative encyclopedia of DNA elements in the mouse genome. |
| title_sort | comparative encyclopedia of dna elements in the mouse genome |
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