Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse

Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse

Ligation of T cell receptor (TCR) to peptide-MHC (pMHC) complexes initiates signaling leading to T cell activation and TCR ubiquitination. Ubiquitinated TCR is then either internalized by the T cell or released toward the antigen-presenting cell (APC) in extracellular vesicles. How these distinct fa...

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Dettagli Bibliografici
Autori principali:	Kvalvaag, A, Valvo, S, Céspedes, PF, Saliba, DG, Kurz, E, Korobchevskaya, K, Dustin, ML
Natura:	Journal article
Lingua:	English
Pubblicazione:	National Academy of Sciences 2023

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