MICAL-L1-related and unrelated mechanisms underlying elongated tubular endosomal network (ETEN) in human dendritic cells
<p style="text-align:justify;"> The endosomal pathway constitutes a highly dynamic intracellular transport system, which is composed of vesicular and tubular compartments. Endosomal tubules enable geometry-based discrimination between membrane and luminal content. Extended tubular e...
| Κύριοι συγγραφείς: | , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
Taylor and Francis
2014
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| _version_ | 1826286671092514816 |
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| author | Compeer, E Boes, M |
| author_facet | Compeer, E Boes, M |
| author_sort | Compeer, E |
| collection | OXFORD |
| description | <p style="text-align:justify;"> The endosomal pathway constitutes a highly dynamic intracellular transport system, which is composed of vesicular and tubular compartments. Endosomal tubules enable geometry-based discrimination between membrane and luminal content. Extended tubular endosomes were suggested to deliver a steady stream of membrane proteins to one location more reliable and effective than vesicular endosomes. Recently, we demonstrated that human dendritic cells (DCs) form a large elongated tubular endosomal network, e.g. ETEN, upon distinct triggers. LPS-stimulation triggered late endosomal tubulation. Additional clustering of class I MHC and ICAM-1 by a cognate interaction between antigen-laden DC and antigen-specific CD8+ T-cells induces formation of transferrin-positive tubules emanating from the endosomal recycling compartment (ERC). We here discuss cell-biological mechanisms that are involved in membrane bending and possibly underlie initiation, elongation, and stabilization of ETEN in human DCs. Using a knock-down approach we demonstrate that MICAL-L1 is necessary for ETEN remodeling originating from ERC in human DCs. </p> |
| first_indexed | 2024-03-07T01:47:12Z |
| format | Journal article |
| id | oxford-uuid:98d2ee29-7a2e-40f8-a90f-1f1e051e043d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:47:12Z |
| publishDate | 2014 |
| publisher | Taylor and Francis |
| record_format | dspace |
| spelling | oxford-uuid:98d2ee29-7a2e-40f8-a90f-1f1e051e043d2022-03-27T00:09:46ZMICAL-L1-related and unrelated mechanisms underlying elongated tubular endosomal network (ETEN) in human dendritic cellsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:98d2ee29-7a2e-40f8-a90f-1f1e051e043dEnglishSymplectic Elements at OxfordTaylor and Francis2014Compeer, EBoes, M <p style="text-align:justify;"> The endosomal pathway constitutes a highly dynamic intracellular transport system, which is composed of vesicular and tubular compartments. Endosomal tubules enable geometry-based discrimination between membrane and luminal content. Extended tubular endosomes were suggested to deliver a steady stream of membrane proteins to one location more reliable and effective than vesicular endosomes. Recently, we demonstrated that human dendritic cells (DCs) form a large elongated tubular endosomal network, e.g. ETEN, upon distinct triggers. LPS-stimulation triggered late endosomal tubulation. Additional clustering of class I MHC and ICAM-1 by a cognate interaction between antigen-laden DC and antigen-specific CD8+ T-cells induces formation of transferrin-positive tubules emanating from the endosomal recycling compartment (ERC). We here discuss cell-biological mechanisms that are involved in membrane bending and possibly underlie initiation, elongation, and stabilization of ETEN in human DCs. Using a knock-down approach we demonstrate that MICAL-L1 is necessary for ETEN remodeling originating from ERC in human DCs. </p> |
| spellingShingle | Compeer, E Boes, M MICAL-L1-related and unrelated mechanisms underlying elongated tubular endosomal network (ETEN) in human dendritic cells |
| title | MICAL-L1-related and unrelated mechanisms underlying elongated tubular endosomal network (ETEN) in human dendritic cells |
| title_full | MICAL-L1-related and unrelated mechanisms underlying elongated tubular endosomal network (ETEN) in human dendritic cells |
| title_fullStr | MICAL-L1-related and unrelated mechanisms underlying elongated tubular endosomal network (ETEN) in human dendritic cells |
| title_full_unstemmed | MICAL-L1-related and unrelated mechanisms underlying elongated tubular endosomal network (ETEN) in human dendritic cells |
| title_short | MICAL-L1-related and unrelated mechanisms underlying elongated tubular endosomal network (ETEN) in human dendritic cells |
| title_sort | mical l1 related and unrelated mechanisms underlying elongated tubular endosomal network eten in human dendritic cells |
| work_keys_str_mv | AT compeere micall1relatedandunrelatedmechanismsunderlyingelongatedtubularendosomalnetworketeninhumandendriticcells AT boesm micall1relatedandunrelatedmechanismsunderlyingelongatedtubularendosomalnetworketeninhumandendriticcells |