The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

Acute Myeloid Leukemia (AML) with MLL gene rearrangements demonstrate unique gene expression profiles driven by MLL-fusion proteins. Here, we identify the circadian clock transcription factor SHARP1 as a novel oncogenic target in MLL-AF6 AML, which has the worst prognosis among all subtypes of MLL-r...

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Main Authors: Numata, A, Kwok, HS, Kawasaki, A, Li, J, Zhou, Q-L, Kerry, J, Benoukraf, T, Bararia, D, Li, F, Ballabio, E, Tapia, M, Deshpande, AJ, Welner, RS, Delwel, R, Yang, H, Milne, TA, Taneja, R, Tenen, DG
פורמט: Journal article
שפה:English
יצא לאור: Springer Nature 2018

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