Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization
Background: Mainland China has experienced five epidemics of human cases of avian influenza A(H7N9) virus infection since 2013. We conducted a prospective study to assess long-term clinical, pulmonary function testing, and chest computed tomography (CT) imaging findings after patients were discharge...
| Những tác giả chính: | , , , , , , , , , , , , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
Elsevier
2020
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| _version_ | 1826286682899480576 |
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| author | Wang, Q Jiang, H Xie, Y Zhang, T Liu, S Wu, S Sun, Q Song, S Wang, W Deng, X Ren, L Qin, T Horby, P Uyeki, T Yu, H |
| author_facet | Wang, Q Jiang, H Xie, Y Zhang, T Liu, S Wu, S Sun, Q Song, S Wang, W Deng, X Ren, L Qin, T Horby, P Uyeki, T Yu, H |
| author_sort | Wang, Q |
| collection | OXFORD |
| description | Background: Mainland China has experienced five epidemics of human cases of avian influenza A(H7N9) virus
infection since 2013. We conducted a prospective study to assess long-term clinical, pulmonary function
testing, and chest computed tomography (CT) imaging findings after patients were discharged from hospital.
Methods: A(H7N9) survivors in five provinces and one municipality underwent follow-up visits from August
2013 to September 2018, at three, six, and 12 months after illness onset, and a subset was also assessed at 18
and 64 months after onset. Thirteen patients were enrolled from the first A(H7N9) epidemic in 2013, 36
from the 2013-2014 second epidemic, and 12 from the 2016-2017 fifth epidemic. At each visit, A(H7N9) survivors received a medical examination, including the mMRC (modified Medical Research Council) dyspnea
scale assessment, chest auscultation, pulmonary function testing and chest CT scans.
Findings: The median age of 61 A(H7N9) survivors was 50 years. The cumulative rate of pulmonary dysfunction
was 38¢5% and 78¢2% for chest CT scan abnormalities at the end of follow-up. Restrictive ventilation dysfunction
was common during follow-up. Mild dyspnea was documented at three to 12-month follow-up visits.
Interpretation: Patients who survived severe illness from A(H7N9) virus infection had evidence of persistent
lung damage and long-term pulmonary dysfunction. |
| first_indexed | 2024-03-07T01:47:22Z |
| format | Journal article |
| id | oxford-uuid:98e3b498-db67-4e8b-badc-22846b4f6ebd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:47:22Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:98e3b498-db67-4e8b-badc-22846b4f6ebd2022-03-27T00:10:18ZLong-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalizationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:98e3b498-db67-4e8b-badc-22846b4f6ebdEnglishSymplectic ElementsElsevier2020Wang, QJiang, HXie, YZhang, TLiu, SWu, SSun, QSong, SWang, WDeng, XRen, LQin, THorby, PUyeki, TYu, HBackground: Mainland China has experienced five epidemics of human cases of avian influenza A(H7N9) virus infection since 2013. We conducted a prospective study to assess long-term clinical, pulmonary function testing, and chest computed tomography (CT) imaging findings after patients were discharged from hospital. Methods: A(H7N9) survivors in five provinces and one municipality underwent follow-up visits from August 2013 to September 2018, at three, six, and 12 months after illness onset, and a subset was also assessed at 18 and 64 months after onset. Thirteen patients were enrolled from the first A(H7N9) epidemic in 2013, 36 from the 2013-2014 second epidemic, and 12 from the 2016-2017 fifth epidemic. At each visit, A(H7N9) survivors received a medical examination, including the mMRC (modified Medical Research Council) dyspnea scale assessment, chest auscultation, pulmonary function testing and chest CT scans. Findings: The median age of 61 A(H7N9) survivors was 50 years. The cumulative rate of pulmonary dysfunction was 38¢5% and 78¢2% for chest CT scan abnormalities at the end of follow-up. Restrictive ventilation dysfunction was common during follow-up. Mild dyspnea was documented at three to 12-month follow-up visits. Interpretation: Patients who survived severe illness from A(H7N9) virus infection had evidence of persistent lung damage and long-term pulmonary dysfunction. |
| spellingShingle | Wang, Q Jiang, H Xie, Y Zhang, T Liu, S Wu, S Sun, Q Song, S Wang, W Deng, X Ren, L Qin, T Horby, P Uyeki, T Yu, H Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization |
| title | Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization |
| title_full | Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization |
| title_fullStr | Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization |
| title_full_unstemmed | Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization |
| title_short | Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization |
| title_sort | long term clinical prognosis of human infections with avian influenza a h7n9 viruses in china after hospitalization |
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