Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

他のバージョン（1件）を表示する

There is a growing recognition of the importance of protein kinases in the control of alternative splicing. To define the underlying regulatory mechanisms, highly selective inhibitors are needed. Here, we report the discovery and characterization of the dichloroindolyl enaminonitrile KH-CB19, a pote...

書誌詳細
主要な著者:	Fedorov, O, Huber, K, Eisenreich, A, Filippakopoulos, P, King, O, Bullock, A, Szklarczyk, D, Jensen, L, Fabbro, D, Trappe, J, Rauch, U, Bracher, F, Knapp, S
フォーマット:	Journal article
言語:	English
出版事項:	2011

類似資料

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.
著者:: Fedorov, O, 等
出版事項: (2011)

7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.
著者:: Huber, K, 等
出版事項: (2012)

Regulation of influenza A virus mRNA splicing by CLK1
著者:: Artarini, A, 等
出版事項: (2019)

CLK2 blockade modulates alternative splicing compromising MYC‐driven breast tumors
著者:: Fernando Salvador, 等
出版事項: (2018-05-01)

Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2
著者:: Maya L Bulos, 等
出版事項: (2023-12-01)

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
著者:: Bullock, A, 等
出版事項: (2009)

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation
著者:: Bullock, A, 等
出版事項: (2009)

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
著者:: Elizabeth Bowler, 等
出版事項: (2018-04-01)

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.
著者:: Debdab, M, 等
出版事項: (2011)

Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability
著者:: Kenichi Iwai, 等
出版事項: (2018-05-01)

Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing.
著者:: Shinsuke Araki, 等
出版事項: (2015-01-01)

DFG-1 residue controls inhibitor binding mode and affinity, providing a basis for rational design of kinase inhibitor selectivity
著者:: Schröder, M, 等
出版事項: (2020)

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.
著者:: Filippakopoulos, P, 等
出版事項: (2012)

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family
著者:: Filippakopoulos, P, 等
出版事項: (2012)

Clk/STY (cdc2-like kinase 1) and Akt regulate alternative splicing and adipogenesis in 3T3-L1 pre-adipocytes.
著者:: Pengfei Li, 等
出版事項: (2013-01-01)

CLK1/CLK2-driven signalling at the Leishmania kinetochore is captured by spatially referenced proximity phosphoproteomics
著者:: Vincent Geoghegan, 等
出版事項: (2022-11-01)

Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases
著者:: Viet Hung Dao, 等
出版事項: (2021-10-01)

Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression
著者:: Jasper Van Goubergen, 等
出版事項: (2025-02-01)

Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors.
著者:: Aiko Murai, 等
出版事項: (2020-01-01)

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype
著者:: Walter, A, 等
出版事項: (2018)

5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency
著者:: Ahmed K. ElHady, 等
出版事項: (2021-02-01)

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.
著者:: Anne Walter, 等
出版事項: (2018-01-01)

Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission.
著者:: Selina Kern, 等
出版事項: (2014-01-01)

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity.
著者:: Pogacic, V, 等
出版事項: (2007)

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
著者:: Tyler Funnell, 等
出版事項: (2017-02-01)

Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.
著者:: Shamila S Gunatilleke, 等
出版事項: (2012-01-01)

Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
著者:: Joanne Tan, 等
出版事項: (2017-11-01)

CLK3 promotes tumor proliferation by activating MYC signaling
著者:: Jing Shen, 等
出版事項: (2024-09-01)

Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes
著者:: Lori Ferrins, 等
出版事項: (2023-05-01)

Development of selective CBP/P300 benzoxazepine bromodomain inhibitors
著者:: Popp, T, 等
出版事項: (2016)

CLK2 Condensates Reorganize Nuclear Speckles and Induce Intron Retention
著者:: Bing Wang, 等
出版事項: (2024-10-01)

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors.
著者:: Christian Schmitt, 等
出版事項: (2014-01-01)

The design and synthesis of 5-and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains
著者:: Hay, D, 等
出版事項: (2013)

Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes
著者:: Lori Ferrins, 等
出版事項: (2023-10-01)

Discrimination of fennel chemotypes applying IR and Raman spectroscopy – discovery of a new -asarone chemotype
著者:: Krähmer, Andrea, 等
出版事項: (2016-07-01)

Calculation of Splicing Potential from the Alternative Splicing Mutation Database
著者:: Afonin Kirill A, 等
出版事項: (2008-02-01)

Developing small molecule inhibitors of the CREBBP bromodomain-histone interaction
著者:: Rooney, T, 等
出版事項: (2012)

The Alternative Splicing Mutation Database: a hub for investigations of alternative splicing using mutational evidence
著者:: Afonin Kirill A, 等
出版事項: (2008-02-01)

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
著者:: Subha Dahal, 等
出版事項: (2022-08-01)

In depth investigation of the metabolism of Nectandra megapotamica chemotypes.
著者:: Katyuce de S Farias, 等
出版事項: (2018-01-01)