Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients
Given the immune system's importance for cancer surveillance and treatment, we have investigated how it may be affected by SARS-CoV-2 infection of cancer patients. Across some heterogeneity in tumor type, stage, and treatment, virus-exposed solid cancer patients display a dominant impact of SAR...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Cell Press
2021
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| _version_ | 1797108120897454080 |
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| author | Abdul-Jawad, S Baù, L Alaguthurai, T Del Molino Del Barrio, I Laing, AG Hayday, TS Monin, L Muñoz-Ruiz, M McDonald, L Francos Quijorna, I McKenzie, D Davis, R Lorenc, A Chan, JNE Ryan, S Bugallo-Blanco, E Yorke, R Kamdar, S Fish, M Zlatareva, I Vantourout, P Jennings, A Gee, S Doores, K Bailey, K Hazell, S De Naurois, J Moss, C Russell, B Khan, AA Rowley, M Benjamin, R Enting, D Alrifai, D Wu, Y Zhou, Y Barber, P Ng, T Spicer, J Van Hemelrijck, M Kumar, M Vidler, J Lwin, Y Fields, P Karagiannis, SN Coolen, ACC Rigg, A Papa, S Hayday, AC Patten, PEM |
| author_facet | Abdul-Jawad, S Baù, L Alaguthurai, T Del Molino Del Barrio, I Laing, AG Hayday, TS Monin, L Muñoz-Ruiz, M McDonald, L Francos Quijorna, I McKenzie, D Davis, R Lorenc, A Chan, JNE Ryan, S Bugallo-Blanco, E Yorke, R Kamdar, S Fish, M Zlatareva, I Vantourout, P Jennings, A Gee, S Doores, K Bailey, K Hazell, S De Naurois, J Moss, C Russell, B Khan, AA Rowley, M Benjamin, R Enting, D Alrifai, D Wu, Y Zhou, Y Barber, P Ng, T Spicer, J Van Hemelrijck, M Kumar, M Vidler, J Lwin, Y Fields, P Karagiannis, SN Coolen, ACC Rigg, A Papa, S Hayday, AC Patten, PEM |
| author_sort | Abdul-Jawad, S |
| collection | OXFORD |
| description | Given the immune system's importance for cancer surveillance and treatment, we have investigated how it may be affected by SARS-CoV-2 infection of cancer patients. Across some heterogeneity in tumor type, stage, and treatment, virus-exposed solid cancer patients display a dominant impact of SARS-CoV-2, apparent from the resemblance of their immune signatures to those for COVID-19+ non-cancer patients. This is not the case for hematological malignancies, with virus-exposed patients collectively displaying heterogeneous humoral responses, an exhausted T cell phenotype and a high prevalence of prolonged virus shedding. Furthermore, while recovered solid cancer patients' immunophenotypes resemble those of non-virus-exposed cancer patients, recovered hematological cancer patients display distinct, lingering immunological legacies. Thus, while solid cancer patients, including those with advanced disease, seem no more at risk of SARS-CoV-2-associated immune dysregulation than the general population, hematological cancer patients show complex immunological consequences of SARS-CoV-2 exposure that might usefully inform their care. |
| first_indexed | 2024-03-07T07:23:07Z |
| format | Journal article |
| id | oxford-uuid:98e6ccc9-a446-4543-8220-de65ab0f3732 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:23:07Z |
| publishDate | 2021 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:98e6ccc9-a446-4543-8220-de65ab0f37322022-11-08T11:38:53ZAcute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patientsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:98e6ccc9-a446-4543-8220-de65ab0f3732EnglishSymplectic ElementsCell Press2021Abdul-Jawad, SBaù, LAlaguthurai, TDel Molino Del Barrio, ILaing, AGHayday, TSMonin, LMuñoz-Ruiz, MMcDonald, LFrancos Quijorna, IMcKenzie, DDavis, RLorenc, AChan, JNERyan, SBugallo-Blanco, EYorke, RKamdar, SFish, MZlatareva, IVantourout, PJennings, AGee, SDoores, KBailey, KHazell, SDe Naurois, JMoss, CRussell, BKhan, AARowley, MBenjamin, REnting, DAlrifai, DWu, YZhou, YBarber, PNg, TSpicer, JVan Hemelrijck, MKumar, MVidler, JLwin, YFields, PKaragiannis, SNCoolen, ACCRigg, APapa, SHayday, ACPatten, PEMGiven the immune system's importance for cancer surveillance and treatment, we have investigated how it may be affected by SARS-CoV-2 infection of cancer patients. Across some heterogeneity in tumor type, stage, and treatment, virus-exposed solid cancer patients display a dominant impact of SARS-CoV-2, apparent from the resemblance of their immune signatures to those for COVID-19+ non-cancer patients. This is not the case for hematological malignancies, with virus-exposed patients collectively displaying heterogeneous humoral responses, an exhausted T cell phenotype and a high prevalence of prolonged virus shedding. Furthermore, while recovered solid cancer patients' immunophenotypes resemble those of non-virus-exposed cancer patients, recovered hematological cancer patients display distinct, lingering immunological legacies. Thus, while solid cancer patients, including those with advanced disease, seem no more at risk of SARS-CoV-2-associated immune dysregulation than the general population, hematological cancer patients show complex immunological consequences of SARS-CoV-2 exposure that might usefully inform their care. |
| spellingShingle | Abdul-Jawad, S Baù, L Alaguthurai, T Del Molino Del Barrio, I Laing, AG Hayday, TS Monin, L Muñoz-Ruiz, M McDonald, L Francos Quijorna, I McKenzie, D Davis, R Lorenc, A Chan, JNE Ryan, S Bugallo-Blanco, E Yorke, R Kamdar, S Fish, M Zlatareva, I Vantourout, P Jennings, A Gee, S Doores, K Bailey, K Hazell, S De Naurois, J Moss, C Russell, B Khan, AA Rowley, M Benjamin, R Enting, D Alrifai, D Wu, Y Zhou, Y Barber, P Ng, T Spicer, J Van Hemelrijck, M Kumar, M Vidler, J Lwin, Y Fields, P Karagiannis, SN Coolen, ACC Rigg, A Papa, S Hayday, AC Patten, PEM Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients |
| title | Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients |
| title_full | Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients |
| title_fullStr | Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients |
| title_full_unstemmed | Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients |
| title_short | Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients |
| title_sort | acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus 2 infected cancer patients |
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