Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells

Cytotoxic T lymphocytes (CTLs) kill infected and cancerous cells. We detected transfer of cytotoxic multiprotein complexes from CTLs to target cells, termed supramolecular attack particles (SMAPs). SMAPs were rapidly released from CTLs and were autonomously cytotoxic. Mass spectrometry, immunochemic...

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Main Authors: Balint, Š, Müller, S, Fischer, R, Kessler, BM, Harkiolaki, M, Valitutti, S, Dustin, ML
格式: Journal article
语言:English
出版: American Association for the Advancement of Science 2020