Structural insight into BLM recognition by TopBP1

Structural insight into BLM recognition by TopBP1

Topoisomerase IIβ binding protein 1 (TopBP1) is a critical protein-protein interaction hub in DNA replication checkpoint control. It was proposed that TopBP1 BRCT5 interacts with Bloom syndrome helicase (BLM) to regulate genome stability through either phospho-Ser304 or phospho-Ser338 of BLM. Here w...

Bibliográfalaš dieđut
Váldodahkkit:	Sun, L, Huang, Y, Edwards, R, Yang, S, Blackford, A, Niedzwiedz, W, Glover, J
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	Elsevier 2017

Geahča maid

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MDC1 interacts with TOPBP1 to maintain chromosomal stability during Mitosis
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Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
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The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis
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BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution
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MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks.
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SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state
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Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)
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Almmustuhtton: (2019-11-01)

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands
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Almmustuhtton: (2018-10-01)

Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila.
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Almmustuhtton: (2011-10-01)

Value engineering on Saga BLM rear axle /
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A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation
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BLM prevents instability of structure-forming DNA sequences at common fragile sites.
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Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome – insights into the enzyme activation mechanism
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