Structural insight into BLM recognition by TopBP1

Structural insight into BLM recognition by TopBP1

Topoisomerase IIβ binding protein 1 (TopBP1) is a critical protein-protein interaction hub in DNA replication checkpoint control. It was proposed that TopBP1 BRCT5 interacts with Bloom syndrome helicase (BLM) to regulate genome stability through either phospho-Ser304 or phospho-Ser338 of BLM. Here w...

Bibliografski detalji
Glavni autori:	Sun, L, Huang, Y, Edwards, R, Yang, S, Blackford, A, Niedzwiedz, W, Glover, J
Format:	Journal article
Jezik:	English
Izdano:	Elsevier 2017

Slični predmeti

Understanding the role of the TOPBP1 and BLM interaction in promoting genome stability
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The Role of DNA Topoisomerase Binding Protein 1 (TopBP1) in Genome Stability in <i>Arabidopsis</i>
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od: Su-Jiun Lin, i dr.
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MDC1 interacts with TOPBP1 to maintain chromosomal stability during Mitosis
od: Leimbacher, P-A, i dr.
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Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
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CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle
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od: Clémence Mooser, i dr.
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od: Chatterjee, S, i dr.
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MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks.
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Baulückenmanagement (BLM) Berlin
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Structure-function analysis of TOPBP1’s role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system
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Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)
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BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands
od: Matthew Day, i dr.
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A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation
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BLM prevents instability of structure-forming DNA sequences at common fragile sites.
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Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome – insights into the enzyme activation mechanism
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BLM and RMI1 alleviate RPA inhibition of TopoIIIα decatenase activity.
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Study of front suspension kinematics of Proton Saga BLM /
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