Design of vaccine efficacy trials during public health emergencies

Public health emergencies, such as an Ebola disease outbreak, provide a complex and challenging environment for the evaluation of candidate vaccines. Here, we outline the need for flexible and responsive vaccine trial designs to be used in public health emergencies, and we summarize recommendations...

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Bibliographic Details
Main Authors: Dean, N, Gsell, P-S, Brookmeyer, R, De Gruttola, V, Donnelly, CA, Halloran, ME, Jasseh, M, Nason, M, Riveros, X, Watson, CH, Henao-Restrepo, A-M, Longini, IM
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2019