Common variants at 6p21.1 are associated with large artery atherosclerotic stroke
Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
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2012
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| author | Holliday, E Holliday, E Maguire, J Maguire, J Maguire, J Evans, T Evans, T Koblar, SA Koblar, SA Jannes, J Jannes, J Sturm, J Sturm, J Hankey, G Hankey, G Baker, R Baker, R Golledge, J Golledge, J Parsons, M Malik, R McEvoy, M McEvoy, M McEvoy, M Biros, E |
| author_facet | Holliday, E Holliday, E Maguire, J Maguire, J Maguire, J Evans, T Evans, T Koblar, SA Koblar, SA Jannes, J Jannes, J Sturm, J Sturm, J Hankey, G Hankey, G Baker, R Baker, R Golledge, J Golledge, J Parsons, M Malik, R McEvoy, M McEvoy, M McEvoy, M Biros, E |
| author_sort | Holliday, E |
| collection | OXFORD |
| description | Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher and more significant for the LAA subtype. We identified a new LAA susceptibility locus on chromosome 6p21.1 (rs556621: odds ratio (OR) = 1.62, P = 3.9 × 10-8) and replicated this association in 1,715 LAA cases and 52,695 population controls from 10 independent population cohorts (meta-analysis replication OR = 1.15, P = 3.9 × 10-4; discovery and replication combined OR = 1.21, P = 4.7 × 10-8). This study identifies a genetic risk locus for LAA and shows how analyzing etiological subtypes may better identify genetic risk alleles for ischemic stroke. © 2012 Nature America, Inc. All rights reserved. |
| first_indexed | 2024-03-07T01:48:24Z |
| format | Journal article |
| id | oxford-uuid:99373d15-b0ec-41f6-b5e0-a134d66e13cb |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:48:24Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:99373d15-b0ec-41f6-b5e0-a134d66e13cb2022-03-27T00:12:43ZCommon variants at 6p21.1 are associated with large artery atherosclerotic strokeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:99373d15-b0ec-41f6-b5e0-a134d66e13cbSymplectic Elements at Oxford2012Holliday, EHolliday, EMaguire, JMaguire, JMaguire, JEvans, TEvans, TKoblar, SAKoblar, SAJannes, JJannes, JSturm, JSturm, JHankey, GHankey, GBaker, RBaker, RGolledge, JGolledge, JParsons, MMalik, RMcEvoy, MMcEvoy, MMcEvoy, MBiros, EGenome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher and more significant for the LAA subtype. We identified a new LAA susceptibility locus on chromosome 6p21.1 (rs556621: odds ratio (OR) = 1.62, P = 3.9 × 10-8) and replicated this association in 1,715 LAA cases and 52,695 population controls from 10 independent population cohorts (meta-analysis replication OR = 1.15, P = 3.9 × 10-4; discovery and replication combined OR = 1.21, P = 4.7 × 10-8). This study identifies a genetic risk locus for LAA and shows how analyzing etiological subtypes may better identify genetic risk alleles for ischemic stroke. © 2012 Nature America, Inc. All rights reserved. |
| spellingShingle | Holliday, E Holliday, E Maguire, J Maguire, J Maguire, J Evans, T Evans, T Koblar, SA Koblar, SA Jannes, J Jannes, J Sturm, J Sturm, J Hankey, G Hankey, G Baker, R Baker, R Golledge, J Golledge, J Parsons, M Malik, R McEvoy, M McEvoy, M McEvoy, M Biros, E Common variants at 6p21.1 are associated with large artery atherosclerotic stroke |
| title | Common variants at 6p21.1 are associated with large artery atherosclerotic stroke |
| title_full | Common variants at 6p21.1 are associated with large artery atherosclerotic stroke |
| title_fullStr | Common variants at 6p21.1 are associated with large artery atherosclerotic stroke |
| title_full_unstemmed | Common variants at 6p21.1 are associated with large artery atherosclerotic stroke |
| title_short | Common variants at 6p21.1 are associated with large artery atherosclerotic stroke |
| title_sort | common variants at 6p21 1 are associated with large artery atherosclerotic stroke |
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