Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4.
Syndecan-4 is a ubiquitously expressed heparan sulfate proteoglycan that modulates cell interactions with the extracellular matrix. It is transiently up-regulated during tissue repair by cells that mediate wound healing. Here, we report that syndecan-4 is essential for optimal fibroblast response to...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1826286767546826752 |
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| author | Midwood, K Valenick, L Hsia, H Schwarzbauer, J |
| author_facet | Midwood, K Valenick, L Hsia, H Schwarzbauer, J |
| author_sort | Midwood, K |
| collection | OXFORD |
| description | Syndecan-4 is a ubiquitously expressed heparan sulfate proteoglycan that modulates cell interactions with the extracellular matrix. It is transiently up-regulated during tissue repair by cells that mediate wound healing. Here, we report that syndecan-4 is essential for optimal fibroblast response to the three-dimensional fibrin-fibronectin provisional matrix that is deposited upon tissue injury. Interference with syndecan-4 function inhibits matrix contraction by preventing cell spreading, actin stress fiber formation, and activation of focal adhesion kinase and RhoA mediated-intracellular signaling pathways. Tenascin-C is an extracellular matrix protein that regulates cell response to fibronectin within the provisional matrix. Syndecan-4 is also required for tenascin-C action. Inhibition of syndecan-4 function suppresses tenascin-C activity and overexpression of syndecan-4 circumvents the effects of tenascin-C. In this way, tenascin-C and syndecan-4 work together to control fibroblast morphology and signaling and regulate events such as matrix contraction that are essential for efficient tissue repair. |
| first_indexed | 2024-03-07T01:48:37Z |
| format | Journal article |
| id | oxford-uuid:994a224d-fb6a-4ae0-8016-cb550bc8f2ad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:48:37Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:994a224d-fb6a-4ae0-8016-cb550bc8f2ad2022-03-27T00:13:14ZCoregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:994a224d-fb6a-4ae0-8016-cb550bc8f2adEnglishSymplectic Elements at Oxford2004Midwood, KValenick, LHsia, HSchwarzbauer, JSyndecan-4 is a ubiquitously expressed heparan sulfate proteoglycan that modulates cell interactions with the extracellular matrix. It is transiently up-regulated during tissue repair by cells that mediate wound healing. Here, we report that syndecan-4 is essential for optimal fibroblast response to the three-dimensional fibrin-fibronectin provisional matrix that is deposited upon tissue injury. Interference with syndecan-4 function inhibits matrix contraction by preventing cell spreading, actin stress fiber formation, and activation of focal adhesion kinase and RhoA mediated-intracellular signaling pathways. Tenascin-C is an extracellular matrix protein that regulates cell response to fibronectin within the provisional matrix. Syndecan-4 is also required for tenascin-C action. Inhibition of syndecan-4 function suppresses tenascin-C activity and overexpression of syndecan-4 circumvents the effects of tenascin-C. In this way, tenascin-C and syndecan-4 work together to control fibroblast morphology and signaling and regulate events such as matrix contraction that are essential for efficient tissue repair. |
| spellingShingle | Midwood, K Valenick, L Hsia, H Schwarzbauer, J Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4. |
| title | Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4. |
| title_full | Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4. |
| title_fullStr | Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4. |
| title_full_unstemmed | Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4. |
| title_short | Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4. |
| title_sort | coregulation of fibronectin signaling and matrix contraction by tenascin c and syndecan 4 |
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