FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

The transcription factor FOXN1 is a master regulator of thymic epithelial cell (TEC) development and function. Here, we demonstrate that FOXN1 expression is differentially regulated during organogenesis and participates in multimolecular nuclear condensates essential for the factor’s transcriptional...

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Main Authors:	Rota, I, Handel, A, Maio, S, Klein, F, Dhalla, F, Deadman, M, Cheuk, S, Newman, J, Michaels, Y, Zuklys, S, Prevot, N, Hublitz, P, Charles, P, Gkazi, A, Adamopoulou, E, Quasim, W, Davies, EG, Hanson, C, Pagnamenta, A, Camps, C, Dreau, H, White, A, James, K, Fischer, R, Gileadi, O, Taylor, J, Fulga, T, Lagerholm, BC, Anderson, G, Sezgin, E, Hollander, G
格式:	Journal article
语言:	English
出版:	American Association for the Advancement of Science 2021

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

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