Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults
<p><strong>Objective</strong> Aim to examine the independent and joint associations of physical activity (PA) and sedentary leisure-time (SLT) with risk of diabetes and assess the extent to which these associations were mediated by adiposity.</p> <p><strong>Resear...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
BMJ Publishing Group
2019
|
| _version_ | 1797083966908399616 |
|---|---|
| author | Bennett, D Du, H Bragg, F Guo, Y Wright, N Yang, L Bian, Z Chen, Y Yu, C Wang, S Meng, F Lv, J Chen, J Li, L Clarke, R Chen, Z on behalf of the China Kadoorie Biobank Study Collaborative Group |
| author_facet | Bennett, D Du, H Bragg, F Guo, Y Wright, N Yang, L Bian, Z Chen, Y Yu, C Wang, S Meng, F Lv, J Chen, J Li, L Clarke, R Chen, Z on behalf of the China Kadoorie Biobank Study Collaborative Group |
| author_sort | Bennett, D |
| collection | OXFORD |
| description | <p><strong>Objective</strong> Aim to examine the independent and joint associations of physical activity (PA) and sedentary leisure-time (SLT) with risk of diabetes and assess the extent to which these associations were mediated by adiposity.</p> <p><strong>Research design and methods</strong> The prospective China Kadoorie Biobank recruited ~512 000 adults from 10 diverse areas across China. Self-reported PA was estimated based on type, frequency and duration of specific types of PA, covering four domains (occupation, leisure, household and commuting). SLT was defined as hours per day spent watching television, reading or playing card games. Stratified Cox proportional hazards models were used to estimate adjusted HRs (aHRs) for PA and SLT associated with incident diabetes. Analyses were stratified by age-at-risk (5-year intervals), sex and region and adjusted for household income, education, alcohol consumption, smoking, fresh fruit intake, self-reported general health status, family history of diabetes and body mass index (BMI) status. Analyses of total PA, occupational and non-occupational PA and SLT were mutually adjusted for each other, as appropriate.</p> <p><strong>Results</strong> After ~9 years of follow-up, there were 14 940 incident diabetes cases among 460 736 participants without prior diabetes or cardiovascular diseases at baseline. The mean (SD) age at baseline was 51 (10.6) years, 59% were women and 43% resided in urban areas. Overall, the mean BMI was 23.5 (3.3) kg/m2, which differed by ~0.5 kg/m2 among individuals in the highest compared with the lowest PA and SLT groups. PA was inversely associated the risk of diabetes 16% (aHR: 0.84, 95% CI 0.81 to 0.88) lower in top than bottom fifth. After further adjustment for BMI this was attenuated to 0.99 (95% CI 0.98 to 1.00). SLT was positively associated with diabetes and each 1 hour per day higher usual level was associated with aHR of 1.13 (95% CI 1.09 to 1.17) for diabetes, attenuated to 1.05 (95% CI 1.01 to 1.09) after further adjustment for BMI.</p> <p><strong>Conclusions</strong> Among Chinese adults, higher levels of PA and lower levels of SLT were associated with lower risks of diabetes with no evidence of effect modification by each other. These associations appeared to arise mainly through adiposity.</p> |
| first_indexed | 2024-03-07T01:49:02Z |
| format | Journal article |
| id | oxford-uuid:996fbcc5-5606-4957-a6d6-7bae2c078931 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:49:02Z |
| publishDate | 2019 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:996fbcc5-5606-4957-a6d6-7bae2c0789312022-03-27T00:14:20ZPhysical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adultsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:996fbcc5-5606-4957-a6d6-7bae2c078931Symplectic Elements at OxfordBMJ Publishing Group2019Bennett, DDu, HBragg, FGuo, YWright, NYang, LBian, ZChen, YYu, CWang, SMeng, FLv, JChen, JLi, LClarke, RChen, Zon behalf of the China Kadoorie Biobank Study Collaborative Group<p><strong>Objective</strong> Aim to examine the independent and joint associations of physical activity (PA) and sedentary leisure-time (SLT) with risk of diabetes and assess the extent to which these associations were mediated by adiposity.</p> <p><strong>Research design and methods</strong> The prospective China Kadoorie Biobank recruited ~512 000 adults from 10 diverse areas across China. Self-reported PA was estimated based on type, frequency and duration of specific types of PA, covering four domains (occupation, leisure, household and commuting). SLT was defined as hours per day spent watching television, reading or playing card games. Stratified Cox proportional hazards models were used to estimate adjusted HRs (aHRs) for PA and SLT associated with incident diabetes. Analyses were stratified by age-at-risk (5-year intervals), sex and region and adjusted for household income, education, alcohol consumption, smoking, fresh fruit intake, self-reported general health status, family history of diabetes and body mass index (BMI) status. Analyses of total PA, occupational and non-occupational PA and SLT were mutually adjusted for each other, as appropriate.</p> <p><strong>Results</strong> After ~9 years of follow-up, there were 14 940 incident diabetes cases among 460 736 participants without prior diabetes or cardiovascular diseases at baseline. The mean (SD) age at baseline was 51 (10.6) years, 59% were women and 43% resided in urban areas. Overall, the mean BMI was 23.5 (3.3) kg/m2, which differed by ~0.5 kg/m2 among individuals in the highest compared with the lowest PA and SLT groups. PA was inversely associated the risk of diabetes 16% (aHR: 0.84, 95% CI 0.81 to 0.88) lower in top than bottom fifth. After further adjustment for BMI this was attenuated to 0.99 (95% CI 0.98 to 1.00). SLT was positively associated with diabetes and each 1 hour per day higher usual level was associated with aHR of 1.13 (95% CI 1.09 to 1.17) for diabetes, attenuated to 1.05 (95% CI 1.01 to 1.09) after further adjustment for BMI.</p> <p><strong>Conclusions</strong> Among Chinese adults, higher levels of PA and lower levels of SLT were associated with lower risks of diabetes with no evidence of effect modification by each other. These associations appeared to arise mainly through adiposity.</p> |
| spellingShingle | Bennett, D Du, H Bragg, F Guo, Y Wright, N Yang, L Bian, Z Chen, Y Yu, C Wang, S Meng, F Lv, J Chen, J Li, L Clarke, R Chen, Z on behalf of the China Kadoorie Biobank Study Collaborative Group Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults |
| title | Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults |
| title_full | Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults |
| title_fullStr | Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults |
| title_full_unstemmed | Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults |
| title_short | Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults |
| title_sort | physical activity sedentary leisure time and risk of incident type 2 diabetes a prospective study of 512 000 chinese adults |
| work_keys_str_mv | AT bennettd physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT duh physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT braggf physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT guoy physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT wrightn physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT yangl physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT bianz physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT cheny physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT yuc physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT wangs physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT mengf physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT lvj physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT chenj physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT lil physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT clarker physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT chenz physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults AT onbehalfofthechinakadooriebiobankstudycollaborativegroup physicalactivitysedentaryleisuretimeandriskofincidenttype2diabetesaprospectivestudyof512000chineseadults |