Exportation of Monkeypox virus from the African continent
<br><strong>Background<br></strong> The largest West African monkeypox outbreak began September 2017, in Nigeria. Four individuals traveling from Nigeria to the United Kingdom (n = 2), Israel (n = 1), and Singapore (n = 1) became the first human monkeypox cases exported from...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2020
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| _version_ | 1826308072436400128 |
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| author | Mauldin, MR McCollum, AM Nakazawa, YJ Mandra, A Whitehouse, ER Davidson, W Zhao, H Gao, J Li, Y Doty, J Yinka-Ogunleye, A Akinpelu, A Aruna, O Naidoo, D Lewandowski, K Afrough, B Graham, V Aarons, E Hewson, R Vipond, R Dunning, J Chand, M Brown, C Cohen-Gihon, I Erez, N Shifman, O Israeli, O Sharon, M Schwartz, E Beth-Din, A Zvi, A Mak, TM Ng, YK Cui, L Lin, RTP Olson, VA Brooks, T Paran, N Ihekweazu, C Reynolds, MG |
| author_facet | Mauldin, MR McCollum, AM Nakazawa, YJ Mandra, A Whitehouse, ER Davidson, W Zhao, H Gao, J Li, Y Doty, J Yinka-Ogunleye, A Akinpelu, A Aruna, O Naidoo, D Lewandowski, K Afrough, B Graham, V Aarons, E Hewson, R Vipond, R Dunning, J Chand, M Brown, C Cohen-Gihon, I Erez, N Shifman, O Israeli, O Sharon, M Schwartz, E Beth-Din, A Zvi, A Mak, TM Ng, YK Cui, L Lin, RTP Olson, VA Brooks, T Paran, N Ihekweazu, C Reynolds, MG |
| author_sort | Mauldin, MR |
| collection | OXFORD |
| description | <br><strong>Background<br></strong>
The largest West African monkeypox outbreak began September 2017, in Nigeria. Four individuals traveling from Nigeria to the United Kingdom (n = 2), Israel (n = 1), and Singapore (n = 1) became the first human monkeypox cases exported from Africa, and a related nosocomial transmission event in the United Kingdom became the first confirmed human-to-human monkeypox transmission event outside of Africa.
<br><strong>
Methods<br></strong>
Epidemiological and molecular data for exported and Nigerian cases were analyzed jointly to better understand the exportations in the temporal and geographic context of the outbreak.
<br><strong>
Results<br></strong>
Isolates from all travelers and a Bayelsa case shared a most recent common ancestor and traveled to Bayelsa, Delta, or Rivers states. Genetic variation for this cluster was lower than would be expected from a random sampling of genomes from this outbreak, but data did not support direct links between travelers.
<br><strong>
Conclusions<br></strong>
Monophyly of exportation cases and the Bayelsa sample, along with the intermediate levels of genetic variation, suggest a small pool of related isolates is the likely source for the exported infections. This may be the result of the level of genetic variation present in monkeypox isolates circulating within the contiguous region of Bayelsa, Delta, and Rivers states, or another more restricted, yet unidentified source pool. |
| first_indexed | 2024-03-07T07:14:06Z |
| format | Journal article |
| id | oxford-uuid:9978f19a-29c1-4115-ae9a-f9d24976e956 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:14:06Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:9978f19a-29c1-4115-ae9a-f9d24976e9562022-07-15T16:12:01ZExportation of Monkeypox virus from the African continentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9978f19a-29c1-4115-ae9a-f9d24976e956EnglishSymplectic ElementsOxford University Press2020Mauldin, MRMcCollum, AMNakazawa, YJMandra, AWhitehouse, ERDavidson, WZhao, HGao, JLi, YDoty, JYinka-Ogunleye, AAkinpelu, AAruna, ONaidoo, DLewandowski, KAfrough, BGraham, VAarons, EHewson, RVipond, RDunning, JChand, MBrown, CCohen-Gihon, IErez, NShifman, OIsraeli, OSharon, MSchwartz, EBeth-Din, AZvi, AMak, TMNg, YKCui, LLin, RTPOlson, VABrooks, TParan, NIhekweazu, CReynolds, MG<br><strong>Background<br></strong> The largest West African monkeypox outbreak began September 2017, in Nigeria. Four individuals traveling from Nigeria to the United Kingdom (n = 2), Israel (n = 1), and Singapore (n = 1) became the first human monkeypox cases exported from Africa, and a related nosocomial transmission event in the United Kingdom became the first confirmed human-to-human monkeypox transmission event outside of Africa. <br><strong> Methods<br></strong> Epidemiological and molecular data for exported and Nigerian cases were analyzed jointly to better understand the exportations in the temporal and geographic context of the outbreak. <br><strong> Results<br></strong> Isolates from all travelers and a Bayelsa case shared a most recent common ancestor and traveled to Bayelsa, Delta, or Rivers states. Genetic variation for this cluster was lower than would be expected from a random sampling of genomes from this outbreak, but data did not support direct links between travelers. <br><strong> Conclusions<br></strong> Monophyly of exportation cases and the Bayelsa sample, along with the intermediate levels of genetic variation, suggest a small pool of related isolates is the likely source for the exported infections. This may be the result of the level of genetic variation present in monkeypox isolates circulating within the contiguous region of Bayelsa, Delta, and Rivers states, or another more restricted, yet unidentified source pool. |
| spellingShingle | Mauldin, MR McCollum, AM Nakazawa, YJ Mandra, A Whitehouse, ER Davidson, W Zhao, H Gao, J Li, Y Doty, J Yinka-Ogunleye, A Akinpelu, A Aruna, O Naidoo, D Lewandowski, K Afrough, B Graham, V Aarons, E Hewson, R Vipond, R Dunning, J Chand, M Brown, C Cohen-Gihon, I Erez, N Shifman, O Israeli, O Sharon, M Schwartz, E Beth-Din, A Zvi, A Mak, TM Ng, YK Cui, L Lin, RTP Olson, VA Brooks, T Paran, N Ihekweazu, C Reynolds, MG Exportation of Monkeypox virus from the African continent |
| title | Exportation of Monkeypox virus from the African continent |
| title_full | Exportation of Monkeypox virus from the African continent |
| title_fullStr | Exportation of Monkeypox virus from the African continent |
| title_full_unstemmed | Exportation of Monkeypox virus from the African continent |
| title_short | Exportation of Monkeypox virus from the African continent |
| title_sort | exportation of monkeypox virus from the african continent |
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