Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task.
Aged (24 month) rats have previously been shown to manifest delay-dependent deficits in the performance of an operant delayed non-matching to position task. In the present experiment, cholinergic-rich grafts implanted into either the neocortex or the hippocampus of aged rats are shown to reinnervate...
| Main Authors: | , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
1988
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| _version_ | 1826286805754839040 |
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| author | Dunnett, S Badman, F Rogers, D Evenden, J Iversen, S |
| author_facet | Dunnett, S Badman, F Rogers, D Evenden, J Iversen, S |
| author_sort | Dunnett, S |
| collection | OXFORD |
| description | Aged (24 month) rats have previously been shown to manifest delay-dependent deficits in the performance of an operant delayed non-matching to position task. In the present experiment, cholinergic-rich grafts implanted into either the neocortex or the hippocampus of aged rats are shown to reinnervate the host neocortex and hippocampus, respectively, and to provide a significant amelioration of the host animals' short-term memory impairments. The results are discussed in light of the cholinergic hypothesis of geriatric memory dysfunction. |
| first_indexed | 2024-03-07T01:49:11Z |
| format | Journal article |
| id | oxford-uuid:997b1941-f7a6-40f2-8b03-b2cd5a245afb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:49:11Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:997b1941-f7a6-40f2-8b03-b2cd5a245afb2022-03-27T00:14:38ZCholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:997b1941-f7a6-40f2-8b03-b2cd5a245afbEnglishSymplectic Elements at Oxford1988Dunnett, SBadman, FRogers, DEvenden, JIversen, SAged (24 month) rats have previously been shown to manifest delay-dependent deficits in the performance of an operant delayed non-matching to position task. In the present experiment, cholinergic-rich grafts implanted into either the neocortex or the hippocampus of aged rats are shown to reinnervate the host neocortex and hippocampus, respectively, and to provide a significant amelioration of the host animals' short-term memory impairments. The results are discussed in light of the cholinergic hypothesis of geriatric memory dysfunction. |
| spellingShingle | Dunnett, S Badman, F Rogers, D Evenden, J Iversen, S Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task. |
| title | Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task. |
| title_full | Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task. |
| title_fullStr | Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task. |
| title_full_unstemmed | Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task. |
| title_short | Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task. |
| title_sort | cholinergic grafts in the neocortex or hippocampus of aged rats reduction of delay dependent deficits in the delayed non matching to position task |
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