Matrix-targeting immunotherapy controls tumor growth and spread by switching macrophage phenotype

The interplay between cancer cells and immune cells is a key determinant of tumor survival. Here, we uncovered how tumors exploit the immuno-modulatory properties of the extracellular matrix to create a microenvironment that enables their escape from immune surveillance. Using orthotopic grafting o...

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Bibliographic Details
Main Authors: Deligny, C, Murdamoothoo, D, Gammage, A, Gschwandtner, M, Midwood, K
Format: Journal article
Language:English
Published: American Association for Cancer Research 2020

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