Kidney grafts from brain dead donors: Inferior quality or opportunity for improvement?
Major improvements in immunosuppressive treatment, surgical techniques, and treatment of post-transplant complications have contributed considerably to improved outcome in renal transplantation over the past decades. Yet, these accomplishments have not led to similar improvements in transplant outco...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797083998271307776 |
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| author | Bos, E Leuvenink, H van Goor, H Ploeg, R |
| author_facet | Bos, E Leuvenink, H van Goor, H Ploeg, R |
| author_sort | Bos, E |
| collection | OXFORD |
| description | Major improvements in immunosuppressive treatment, surgical techniques, and treatment of post-transplant complications have contributed considerably to improved outcome in renal transplantation over the past decades. Yet, these accomplishments have not led to similar improvements in transplant outcome when the results of living and deceased donors are compared. The enormous demand for donor kidneys has allowed for the increase in acceptance of suboptimal donors. The use of brain dead patients as organ donors has had a tremendous positive influence on the number of renal transplants. Unfortunately, the physiologically abnormal state of brain death has a negative effect on transplant outcome. The fact that transplanted kidneys derived from brain dead donors have a decreased viability indicates that potential grafts are already damaged before retrieval and preservation. In this review, we present an overview of the current knowledge of (patho)-physiological effects of brain death and its relevance for renal transplant outcome. In addition, several options for therapeutic intervention during brain death in the donor with the goal to improve organ viability and transplant outcome are discussed. |
| first_indexed | 2024-03-07T01:49:26Z |
| format | Journal article |
| id | oxford-uuid:9991e369-8ed0-473d-8226-885a64e8a60f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:49:26Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:9991e369-8ed0-473d-8226-885a64e8a60f2022-03-27T00:15:21ZKidney grafts from brain dead donors: Inferior quality or opportunity for improvement?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9991e369-8ed0-473d-8226-885a64e8a60fEnglishSymplectic Elements at Oxford2007Bos, ELeuvenink, Hvan Goor, HPloeg, RMajor improvements in immunosuppressive treatment, surgical techniques, and treatment of post-transplant complications have contributed considerably to improved outcome in renal transplantation over the past decades. Yet, these accomplishments have not led to similar improvements in transplant outcome when the results of living and deceased donors are compared. The enormous demand for donor kidneys has allowed for the increase in acceptance of suboptimal donors. The use of brain dead patients as organ donors has had a tremendous positive influence on the number of renal transplants. Unfortunately, the physiologically abnormal state of brain death has a negative effect on transplant outcome. The fact that transplanted kidneys derived from brain dead donors have a decreased viability indicates that potential grafts are already damaged before retrieval and preservation. In this review, we present an overview of the current knowledge of (patho)-physiological effects of brain death and its relevance for renal transplant outcome. In addition, several options for therapeutic intervention during brain death in the donor with the goal to improve organ viability and transplant outcome are discussed. |
| spellingShingle | Bos, E Leuvenink, H van Goor, H Ploeg, R Kidney grafts from brain dead donors: Inferior quality or opportunity for improvement? |
| title | Kidney grafts from brain dead donors: Inferior quality or opportunity for improvement? |
| title_full | Kidney grafts from brain dead donors: Inferior quality or opportunity for improvement? |
| title_fullStr | Kidney grafts from brain dead donors: Inferior quality or opportunity for improvement? |
| title_full_unstemmed | Kidney grafts from brain dead donors: Inferior quality or opportunity for improvement? |
| title_short | Kidney grafts from brain dead donors: Inferior quality or opportunity for improvement? |
| title_sort | kidney grafts from brain dead donors inferior quality or opportunity for improvement |
| work_keys_str_mv | AT bose kidneygraftsfrombraindeaddonorsinferiorqualityoropportunityforimprovement AT leuveninkh kidneygraftsfrombraindeaddonorsinferiorqualityoropportunityforimprovement AT vangoorh kidneygraftsfrombraindeaddonorsinferiorqualityoropportunityforimprovement AT ploegr kidneygraftsfrombraindeaddonorsinferiorqualityoropportunityforimprovement |