Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.
Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamma h...
| Glavni autori: | , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
1993
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| _version_ | 1826286826802905088 |
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| author | Dalton, D Pitts-Meek, S Keshav, S Figari, I Bradley, A Stewart, T |
| author_facet | Dalton, D Pitts-Meek, S Keshav, S Figari, I Bradley, A Stewart, T |
| author_sort | Dalton, D |
| collection | OXFORD |
| description | Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamma had impaired production of macrophage antimicrobial products and reduced expression of macrophage major histocompatibility complex class II antigens. IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen. After a mixed lymphocyte reaction, T cell cytolytic activity was enhanced against allogeneic target cells. Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system. |
| first_indexed | 2024-03-07T01:49:30Z |
| format | Journal article |
| id | oxford-uuid:9998246c-763e-4cab-b173-c2dea55bf7fb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:49:30Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:9998246c-763e-4cab-b173-c2dea55bf7fb2022-03-27T00:15:19ZMultiple defects of immune cell function in mice with disrupted interferon-gamma genes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9998246c-763e-4cab-b173-c2dea55bf7fbEnglishSymplectic Elements at Oxford1993Dalton, DPitts-Meek, SKeshav, SFigari, IBradley, AStewart, TInterferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamma had impaired production of macrophage antimicrobial products and reduced expression of macrophage major histocompatibility complex class II antigens. IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen. After a mixed lymphocyte reaction, T cell cytolytic activity was enhanced against allogeneic target cells. Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system. |
| spellingShingle | Dalton, D Pitts-Meek, S Keshav, S Figari, I Bradley, A Stewart, T Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. |
| title | Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. |
| title_full | Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. |
| title_fullStr | Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. |
| title_full_unstemmed | Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. |
| title_short | Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. |
| title_sort | multiple defects of immune cell function in mice with disrupted interferon gamma genes |
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