Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220 000 men with 15 years of follow-up
<p><b>Background </b></p> Regular alcohol drinking contributes both favourably and adversely to health in the Western populations, but its effects on overall and cause-specific mortality in China are still poorly understood. <p><b>Methods </b></p> A n...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2012
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| _version_ | 1797112604588507136 |
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| author | Yang, L Zhou, M Sherliker, P Cai, Y Peto, R Wang, L Millwood, I Smith, M Hu, Y Yang, G Chen, Z |
| author_facet | Yang, L Zhou, M Sherliker, P Cai, Y Peto, R Wang, L Millwood, I Smith, M Hu, Y Yang, G Chen, Z |
| author_sort | Yang, L |
| collection | OXFORD |
| description | <p><b>Background </b></p>
Regular alcohol drinking contributes both favourably and adversely to health in the Western populations, but its effects on overall and cause-specific mortality in China are still poorly understood.
<p><b>Methods </b></p>
A nationally representative prospective cohort study included 220 000 men aged 40–79 years from 45 areas in China in 1990–91, and >40 000 deaths occurred during 15 years of follow-up. Cox regression was used to relate alcohol drinking to overall and cause-specific mortality, adjusting for age, area, smoking and education.
<p><b>Results </b></p>
Overall, 33% of the participants reported drinking alcohol regularly at baseline, consuming mainly distilled spirits, with an estimated mean amount consumed of 372 g/week (46.5 units per week). After excluding all men with prior disease at baseline and the first 3 years of follow-up, there was a 5% [95% confidence interval (CI) 2–8] excess risk of overall mortality among regular drinkers. Compared with non-drinkers, the adjusted hazard ratios among men who drank <140, 140–279, 280–419, 420–699 and ≥700 g/week were 0.97, 1.00, 1.02, 1.12 and 1.27, respectively (P < 0.0001 for trend). The strength of the relationship appeared to be greater in smokers than in non-smokers. There was a strong positive association of alcohol drinking with mortality from stroke, oesophageal cancer, liver cirrhosis or accidental causes, a weak J-shaped association with mortality from ischaemic heart disease, stomach cancer and lung cancer and no apparent relationship with respiratory disease mortality.
<p><b>Conclusion </b></p>
Among Chinese men aged 40–79 years, regular alcohol drinking was associated with a small but definite excess risk of overall mortality, especially among smokers. |
| first_indexed | 2024-03-07T08:26:29Z |
| format | Journal article |
| id | oxford-uuid:99cb3280-99d8-4c9f-b208-08e4b3f16e98 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:26:29Z |
| publishDate | 2012 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:99cb3280-99d8-4c9f-b208-08e4b3f16e982024-02-16T16:17:22ZAlcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220 000 men with 15 years of follow-upJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:99cb3280-99d8-4c9f-b208-08e4b3f16e98EnglishSymplectic Elements at OxfordOxford University Press2012Yang, LZhou, MSherliker, PCai, YPeto, RWang, LMillwood, ISmith, MHu, YYang, GChen, Z<p><b>Background </b></p> Regular alcohol drinking contributes both favourably and adversely to health in the Western populations, but its effects on overall and cause-specific mortality in China are still poorly understood. <p><b>Methods </b></p> A nationally representative prospective cohort study included 220 000 men aged 40–79 years from 45 areas in China in 1990–91, and >40 000 deaths occurred during 15 years of follow-up. Cox regression was used to relate alcohol drinking to overall and cause-specific mortality, adjusting for age, area, smoking and education. <p><b>Results </b></p> Overall, 33% of the participants reported drinking alcohol regularly at baseline, consuming mainly distilled spirits, with an estimated mean amount consumed of 372 g/week (46.5 units per week). After excluding all men with prior disease at baseline and the first 3 years of follow-up, there was a 5% [95% confidence interval (CI) 2–8] excess risk of overall mortality among regular drinkers. Compared with non-drinkers, the adjusted hazard ratios among men who drank <140, 140–279, 280–419, 420–699 and ≥700 g/week were 0.97, 1.00, 1.02, 1.12 and 1.27, respectively (P < 0.0001 for trend). The strength of the relationship appeared to be greater in smokers than in non-smokers. There was a strong positive association of alcohol drinking with mortality from stroke, oesophageal cancer, liver cirrhosis or accidental causes, a weak J-shaped association with mortality from ischaemic heart disease, stomach cancer and lung cancer and no apparent relationship with respiratory disease mortality. <p><b>Conclusion </b></p> Among Chinese men aged 40–79 years, regular alcohol drinking was associated with a small but definite excess risk of overall mortality, especially among smokers. |
| spellingShingle | Yang, L Zhou, M Sherliker, P Cai, Y Peto, R Wang, L Millwood, I Smith, M Hu, Y Yang, G Chen, Z Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220 000 men with 15 years of follow-up |
| title | Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220 000 men with 15 years of follow-up |
| title_full | Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220 000 men with 15 years of follow-up |
| title_fullStr | Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220 000 men with 15 years of follow-up |
| title_full_unstemmed | Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220 000 men with 15 years of follow-up |
| title_short | Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220 000 men with 15 years of follow-up |
| title_sort | alcohol drinking and overall and cause specific mortality in china nationally representative prospective study of 220 000 men with 15 years of follow up |
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