Neuronal pathways in tendon healing and tendinopathy--update.
The regulatory mechanisms involved in tendon homeostasis and repair are not fully understood. Accumulating data, however, demonstrate that the nervous system, in addition to afferent (sensory) functions, through efferent pathways plays an active role in regulating pain, inflammation, and tissue repa...
| Príomhchruthaitheoirí: | , , , , , |
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| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
2014
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| _version_ | 1826286870466658304 |
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| author | Ackermann, P Franklin, S Dean, B Carr, A Salo, P Hart, D |
| author_facet | Ackermann, P Franklin, S Dean, B Carr, A Salo, P Hart, D |
| author_sort | Ackermann, P |
| collection | OXFORD |
| description | The regulatory mechanisms involved in tendon homeostasis and repair are not fully understood. Accumulating data, however, demonstrate that the nervous system, in addition to afferent (sensory) functions, through efferent pathways plays an active role in regulating pain, inflammation, and tissue repair. In normal-, healing- and tendinopathic tendons three neurosignalling pathways consisting of autonomic, sensory and glutamatergic neuromediators have been established. In healthy tendons, neuromediators are found in the paratenon, whereas the proper tendon is practically devoid of nerves, reflecting that normal tendon homeostasis is regulated by pro- and anti-inflammatory mediators from the tendon surroundings. During tendon repair, however, there is extensive nerve ingrowth into the tendon proper and subsequent time-dependent appearance of sensory, autonomic and glutamatergic mediators, which amplify and fine-tune inflammation and tendon regeneration. In tendinopathy, excessive and protracted sensory and glutamatergic signalling may be involved in inflammatory, painful and hypertrophic tissue reactions. As our understanding of these processes improves, neuronal mediators may prove to be useful in the development of targeted pharmacotherapy and tissue engineering approaches to painful, degenerative and traumatic tendon disorders. |
| first_indexed | 2024-03-07T01:50:08Z |
| format | Journal article |
| id | oxford-uuid:99ce03aa-ce1b-4732-aab1-c6cb229a1856 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:50:08Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:99ce03aa-ce1b-4732-aab1-c6cb229a18562022-03-27T00:16:57ZNeuronal pathways in tendon healing and tendinopathy--update.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:99ce03aa-ce1b-4732-aab1-c6cb229a1856EnglishSymplectic Elements at Oxford2014Ackermann, PFranklin, SDean, BCarr, ASalo, PHart, DThe regulatory mechanisms involved in tendon homeostasis and repair are not fully understood. Accumulating data, however, demonstrate that the nervous system, in addition to afferent (sensory) functions, through efferent pathways plays an active role in regulating pain, inflammation, and tissue repair. In normal-, healing- and tendinopathic tendons three neurosignalling pathways consisting of autonomic, sensory and glutamatergic neuromediators have been established. In healthy tendons, neuromediators are found in the paratenon, whereas the proper tendon is practically devoid of nerves, reflecting that normal tendon homeostasis is regulated by pro- and anti-inflammatory mediators from the tendon surroundings. During tendon repair, however, there is extensive nerve ingrowth into the tendon proper and subsequent time-dependent appearance of sensory, autonomic and glutamatergic mediators, which amplify and fine-tune inflammation and tendon regeneration. In tendinopathy, excessive and protracted sensory and glutamatergic signalling may be involved in inflammatory, painful and hypertrophic tissue reactions. As our understanding of these processes improves, neuronal mediators may prove to be useful in the development of targeted pharmacotherapy and tissue engineering approaches to painful, degenerative and traumatic tendon disorders. |
| spellingShingle | Ackermann, P Franklin, S Dean, B Carr, A Salo, P Hart, D Neuronal pathways in tendon healing and tendinopathy--update. |
| title | Neuronal pathways in tendon healing and tendinopathy--update. |
| title_full | Neuronal pathways in tendon healing and tendinopathy--update. |
| title_fullStr | Neuronal pathways in tendon healing and tendinopathy--update. |
| title_full_unstemmed | Neuronal pathways in tendon healing and tendinopathy--update. |
| title_short | Neuronal pathways in tendon healing and tendinopathy--update. |
| title_sort | neuronal pathways in tendon healing and tendinopathy update |
| work_keys_str_mv | AT ackermannp neuronalpathwaysintendonhealingandtendinopathyupdate AT franklins neuronalpathwaysintendonhealingandtendinopathyupdate AT deanb neuronalpathwaysintendonhealingandtendinopathyupdate AT carra neuronalpathwaysintendonhealingandtendinopathyupdate AT salop neuronalpathwaysintendonhealingandtendinopathyupdate AT hartd neuronalpathwaysintendonhealingandtendinopathyupdate |