Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation.
Operational tolerance (graft acceptance in an immunosuppression (IS)-free environment) after living-donor liver transplantation (LDLT) could occur by our elective protocol in some patients. There is, nevertheless, no reliable parameter to monitor patients who may discontinue IS without a risk of rej...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Conference item |
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2004
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| _version_ | 1826286896535306240 |
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| author | Li, Y Koshiba, T Yoshizawa, A Yonekawa, Y Masuda, K Ito, A Ueda, M Mori, T Kawamoto, H Tanaka, Y Sakaguchi, S Minato, N Wood, K Tanaka, K |
| author_facet | Li, Y Koshiba, T Yoshizawa, A Yonekawa, Y Masuda, K Ito, A Ueda, M Mori, T Kawamoto, H Tanaka, Y Sakaguchi, S Minato, N Wood, K Tanaka, K |
| author_sort | Li, Y |
| collection | OXFORD |
| description | Operational tolerance (graft acceptance in an immunosuppression (IS)-free environment) after living-donor liver transplantation (LDLT) could occur by our elective protocol in some patients. There is, nevertheless, no reliable parameter to monitor patients who may discontinue IS without a risk of rejection. To identify such parameters, we systemically phenotyped peripheral blood mononuclear cells from operationally tolerant patients. An increase was observed in the frequency of CD4+CD25high+ cells, B cells and Vdelta1/Vdelta2 gammadeltaT-cells ratio in operationally tolerant patients (Gr-tol; n = 12), compared with those from age-matched volunteers (Gr-vol; n = 24) or patients on IS (Gr-IS; n = 19). The frequency of NK cells was decreased in Gr-tol, compared with those in Gr-IS or Gr-vol. The frequency of NKT cells was decreased after LDLT, compared with that in Gr-vol. Although the contribution of those subsets to the tolerant state remains elusive, the results may provide important clues for reliable indicators of tolerance after LDLT. |
| first_indexed | 2024-03-07T01:50:31Z |
| format | Conference item |
| id | oxford-uuid:99ef9e01-6411-471c-b88b-a8c05599c190 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:50:31Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:99ef9e01-6411-471c-b88b-a8c05599c1902022-03-27T00:17:51ZAnalyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:99ef9e01-6411-471c-b88b-a8c05599c190Symplectic Elements at Oxford2004Li, YKoshiba, TYoshizawa, AYonekawa, YMasuda, KIto, AUeda, MMori, TKawamoto, HTanaka, YSakaguchi, SMinato, NWood, KTanaka, KOperational tolerance (graft acceptance in an immunosuppression (IS)-free environment) after living-donor liver transplantation (LDLT) could occur by our elective protocol in some patients. There is, nevertheless, no reliable parameter to monitor patients who may discontinue IS without a risk of rejection. To identify such parameters, we systemically phenotyped peripheral blood mononuclear cells from operationally tolerant patients. An increase was observed in the frequency of CD4+CD25high+ cells, B cells and Vdelta1/Vdelta2 gammadeltaT-cells ratio in operationally tolerant patients (Gr-tol; n = 12), compared with those from age-matched volunteers (Gr-vol; n = 24) or patients on IS (Gr-IS; n = 19). The frequency of NK cells was decreased in Gr-tol, compared with those in Gr-IS or Gr-vol. The frequency of NKT cells was decreased after LDLT, compared with that in Gr-vol. Although the contribution of those subsets to the tolerant state remains elusive, the results may provide important clues for reliable indicators of tolerance after LDLT. |
| spellingShingle | Li, Y Koshiba, T Yoshizawa, A Yonekawa, Y Masuda, K Ito, A Ueda, M Mori, T Kawamoto, H Tanaka, Y Sakaguchi, S Minato, N Wood, K Tanaka, K Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. |
| title | Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. |
| title_full | Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. |
| title_fullStr | Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. |
| title_full_unstemmed | Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. |
| title_short | Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. |
| title_sort | analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation |
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