DNA linkage analysis of X chromosome-linked chronic granulomatous disease.
Chronic granulomatous disease (CGD) is a disorder of phagocytes that is usually inherited as an X chromosome-linked trait. Previous family studies suggested that the CGD locus resides on the distal short arm (Xp22-Xpter). Using cloned, polymorphic DNA probes we have performed a linkage analysis with...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1986
|
| _version_ | 1797084095764758528 |
|---|---|
| author | Baehner, R Kunkel, L Monaco, A Haines, J Conneally, P Palmer, C Heerema, N Orkin, S |
| author_facet | Baehner, R Kunkel, L Monaco, A Haines, J Conneally, P Palmer, C Heerema, N Orkin, S |
| author_sort | Baehner, R |
| collection | OXFORD |
| description | Chronic granulomatous disease (CGD) is a disorder of phagocytes that is usually inherited as an X chromosome-linked trait. Previous family studies suggested that the CGD locus resides on the distal short arm (Xp22-Xpter). Using cloned, polymorphic DNA probes we have performed a linkage analysis within CGD families that suggests a more proximal location (Xp21). In addition, the CGD locus is proximal to the Duchenne muscular dystrophy locus and lies within a broad region of Xp in which recombination appears to be greater than anticipated on the basis of physical distance between markers. Regional localization of the X chromosome CGD locus should facilitate molecular cloning of the CGD gene and molecular dissection of the phagocyte oxidase system. |
| first_indexed | 2024-03-07T01:50:37Z |
| format | Journal article |
| id | oxford-uuid:99f6ca1a-1932-40f4-bec0-21d75d8abe06 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:50:37Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:99f6ca1a-1932-40f4-bec0-21d75d8abe062022-03-27T00:18:03ZDNA linkage analysis of X chromosome-linked chronic granulomatous disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:99f6ca1a-1932-40f4-bec0-21d75d8abe06EnglishSymplectic Elements at Oxford1986Baehner, RKunkel, LMonaco, AHaines, JConneally, PPalmer, CHeerema, NOrkin, SChronic granulomatous disease (CGD) is a disorder of phagocytes that is usually inherited as an X chromosome-linked trait. Previous family studies suggested that the CGD locus resides on the distal short arm (Xp22-Xpter). Using cloned, polymorphic DNA probes we have performed a linkage analysis within CGD families that suggests a more proximal location (Xp21). In addition, the CGD locus is proximal to the Duchenne muscular dystrophy locus and lies within a broad region of Xp in which recombination appears to be greater than anticipated on the basis of physical distance between markers. Regional localization of the X chromosome CGD locus should facilitate molecular cloning of the CGD gene and molecular dissection of the phagocyte oxidase system. |
| spellingShingle | Baehner, R Kunkel, L Monaco, A Haines, J Conneally, P Palmer, C Heerema, N Orkin, S DNA linkage analysis of X chromosome-linked chronic granulomatous disease. |
| title | DNA linkage analysis of X chromosome-linked chronic granulomatous disease. |
| title_full | DNA linkage analysis of X chromosome-linked chronic granulomatous disease. |
| title_fullStr | DNA linkage analysis of X chromosome-linked chronic granulomatous disease. |
| title_full_unstemmed | DNA linkage analysis of X chromosome-linked chronic granulomatous disease. |
| title_short | DNA linkage analysis of X chromosome-linked chronic granulomatous disease. |
| title_sort | dna linkage analysis of x chromosome linked chronic granulomatous disease |
| work_keys_str_mv | AT baehnerr dnalinkageanalysisofxchromosomelinkedchronicgranulomatousdisease AT kunkell dnalinkageanalysisofxchromosomelinkedchronicgranulomatousdisease AT monacoa dnalinkageanalysisofxchromosomelinkedchronicgranulomatousdisease AT hainesj dnalinkageanalysisofxchromosomelinkedchronicgranulomatousdisease AT conneallyp dnalinkageanalysisofxchromosomelinkedchronicgranulomatousdisease AT palmerc dnalinkageanalysisofxchromosomelinkedchronicgranulomatousdisease AT heereman dnalinkageanalysisofxchromosomelinkedchronicgranulomatousdisease AT orkins dnalinkageanalysisofxchromosomelinkedchronicgranulomatousdisease |