Associations between mobility, cognition and brain structure in healthy older adults
Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0±5.1 years), we tested the relationship between mobility measures, cognitive assessme...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
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Frontiers Media
2017
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| _version_ | 1797084165434245120 |
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| author | Demnitz, N Zsoldos, E Mahmood, A Mackay, C Kivimäki, M Singh-Manoux, A Dawes, H Johansen-Berg, H Ebmeier, K Sexton, C |
| author_facet | Demnitz, N Zsoldos, E Mahmood, A Mackay, C Kivimäki, M Singh-Manoux, A Dawes, H Johansen-Berg, H Ebmeier, K Sexton, C |
| author_sort | Demnitz, N |
| collection | OXFORD |
| description | Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0±5.1 years), we tested the relationship between mobility measures, cognitive assessments and MRI markers of brain structure. Mobility was assessed in 2007-2009, using gait, balance and chair-stands tests. In 2012-2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy (FA), axial diffusivity (AD) and radial diffusivity (RD). All mobility measures were positively associated with processing-speed. Faster walking speed was also correlated with higher executive function, while memory was not associated with any mobility measure. Increased GMV within the cerebellum, basal ganglia, post-central gyrus and superior parietal lobe was associated with better mobility. In addition, better performance on the chair-stands test was correlated with decreased RD and AD. Overall, our results indicate that, even in non-clinical populations, mobility measures can be sensitive to sub-clinical variance in cognition and brain structures. |
| first_indexed | 2024-03-07T01:51:33Z |
| format | Journal article |
| id | oxford-uuid:9a4302c1-d2e8-4a1e-8449-d8ba88959fc4 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:51:33Z |
| publishDate | 2017 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:9a4302c1-d2e8-4a1e-8449-d8ba88959fc42022-03-27T00:20:08ZAssociations between mobility, cognition and brain structure in healthy older adultsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9a4302c1-d2e8-4a1e-8449-d8ba88959fc4Symplectic Elements at OxfordFrontiers Media2017Demnitz, NZsoldos, EMahmood, AMackay, CKivimäki, MSingh-Manoux, ADawes, HJohansen-Berg, HEbmeier, KSexton, CMobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0±5.1 years), we tested the relationship between mobility measures, cognitive assessments and MRI markers of brain structure. Mobility was assessed in 2007-2009, using gait, balance and chair-stands tests. In 2012-2015, cognitive testing assessed executive function, memory and processing-speed; gray matter volumes (GMV) were examined using voxel-based morphometry, and white matter microstructure was assessed using tract-based spatial statistics of fractional anisotropy (FA), axial diffusivity (AD) and radial diffusivity (RD). All mobility measures were positively associated with processing-speed. Faster walking speed was also correlated with higher executive function, while memory was not associated with any mobility measure. Increased GMV within the cerebellum, basal ganglia, post-central gyrus and superior parietal lobe was associated with better mobility. In addition, better performance on the chair-stands test was correlated with decreased RD and AD. Overall, our results indicate that, even in non-clinical populations, mobility measures can be sensitive to sub-clinical variance in cognition and brain structures. |
| spellingShingle | Demnitz, N Zsoldos, E Mahmood, A Mackay, C Kivimäki, M Singh-Manoux, A Dawes, H Johansen-Berg, H Ebmeier, K Sexton, C Associations between mobility, cognition and brain structure in healthy older adults |
| title | Associations between mobility, cognition and brain structure in healthy older adults |
| title_full | Associations between mobility, cognition and brain structure in healthy older adults |
| title_fullStr | Associations between mobility, cognition and brain structure in healthy older adults |
| title_full_unstemmed | Associations between mobility, cognition and brain structure in healthy older adults |
| title_short | Associations between mobility, cognition and brain structure in healthy older adults |
| title_sort | associations between mobility cognition and brain structure in healthy older adults |
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