Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms.
World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effect...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1826286972337913856 |
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| author | Laing, G Yarleque, A Marcelo, A Rodriguez, E Warrell, D Theakston, R |
| author_facet | Laing, G Yarleque, A Marcelo, A Rodriguez, E Warrell, D Theakston, R |
| author_sort | Laing, G |
| collection | OXFORD |
| description | World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru. |
| first_indexed | 2024-03-07T01:51:38Z |
| format | Journal article |
| id | oxford-uuid:9a4b6bce-7879-4fe4-a8cc-3ed9223c0d78 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:51:38Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:9a4b6bce-7879-4fe4-a8cc-3ed9223c0d782022-03-27T00:20:21ZPreclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9a4b6bce-7879-4fe4-a8cc-3ed9223c0d78EnglishSymplectic Elements at Oxford2004Laing, GYarleque, AMarcelo, ARodriguez, EWarrell, DTheakston, RWorld Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru. |
| spellingShingle | Laing, G Yarleque, A Marcelo, A Rodriguez, E Warrell, D Theakston, R Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms. |
| title | Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms. |
| title_full | Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms. |
| title_fullStr | Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms. |
| title_full_unstemmed | Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms. |
| title_short | Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms. |
| title_sort | preclinical testing of three south american antivenoms against the venoms of five medically important peruvian snake venoms |
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