The role of ubiquitylation in regulating apurinic/apyrimidinic endonuclease 1

The role of ubiquitylation in regulating apurinic/apyrimidinic endonuclease 1

<p>Apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair factor involved in the DNA base excision repair (BER) pathway that is required for the maintenance of genome stability. In this pathway, APE1 cleaves DNA at an abasic site to generate a DNA single strand break, allowing for rep...

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Detalhes bibliográficos
Autor principal:	Meisenberg, C
Outros Autores:	Dianov, G
Formato:	Thesis
Idioma:	English
Publicado em:	2012
Assuntos:	DNA damage signalling Biology (medical sciences) Radiation Oncology

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