The role of ubiquitylation in regulating apurinic/apyrimidinic endonuclease 1

The role of ubiquitylation in regulating apurinic/apyrimidinic endonuclease 1

<p>Apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair factor involved in the DNA base excision repair (BER) pathway that is required for the maintenance of genome stability. In this pathway, APE1 cleaves DNA at an abasic site to generate a DNA single strand break, allowing for rep...

Полное описание

Библиографические подробности
Главный автор:	Meisenberg, C
Другие авторы:	Dianov, G
Формат:	Диссертация
Язык:	English
Опубликовано:	2012
Предметы:	DNA damage signalling Biology (medical sciences) Radiation Oncology

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