Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems.
BACKGROUND: Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target cell is destroyed. In cytotoxic T lymphocyte...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BioMed Central
2011
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