Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: the effect of clonal complex.
BACKGROUND: Staphylococcus aureus nasal carriage increases infection risk. However, few studies have investigated S. aureus acquisition/loss over >1 year, and fewer still used molecular typing. METHODS: 1123 adults attending five Oxfordshire general practices had nasal swabs taken. 571 were r...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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| _version_ | 1797084214409035776 |
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| author | Miller, R Walker, A Godwin, H Fung, R Votintseva, A Bowden, R Mant, D Peto, T Crook, D Knox, K |
| author_facet | Miller, R Walker, A Godwin, H Fung, R Votintseva, A Bowden, R Mant, D Peto, T Crook, D Knox, K |
| author_sort | Miller, R |
| collection | OXFORD |
| description | BACKGROUND: Staphylococcus aureus nasal carriage increases infection risk. However, few studies have investigated S. aureus acquisition/loss over >1 year, and fewer still used molecular typing. METHODS: 1123 adults attending five Oxfordshire general practices had nasal swabs taken. 571 were re-swabbed after one month then every two months for median two years. All S. aureus isolates were spa-typed. Risk factors were collected from interviews and medical records. RESULTS: 32% carried S. aureus at recruitment (<1% MRSA). Rates of spa-type acquisition were similar in participants S. aureus positive (1.4%/month) and negative (1.8%/month, P = 0.13) at recruitment. Rates were faster in those carrying clonal complex (CC)15 (adjusted (a)P = 0.03) or CC8 (including USA300) (aP = 0.001) at recruitment versus other CCs. 157/274 (57%) participants S. aureus positive at recruitment returning ≥ 12 swabs carried S. aureus consistently, of whom 135 carried the same spa-type. CC22 (including EMRSA-15) was more prevalent in long-term than intermittent spa-type carriers (aP = 0.03). Antibiotics transiently reduced carriage, but no other modifiable risk factors were found. CONCLUSIONS: Both transient and longer-term carriage exist; however, the approximately constant rates of S. aureus gain and loss suggest that 'never' or truly 'persistent' carriage are rare. Long-term carriage varies by strain, offering new explanations for the success of certain S. aureus clones. |
| first_indexed | 2024-03-07T01:52:16Z |
| format | Journal article |
| id | oxford-uuid:9a868d8a-2d12-429a-9e7e-61ca131fcfb5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:52:16Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:9a868d8a-2d12-429a-9e7e-61ca131fcfb52022-03-27T00:21:53ZDynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: the effect of clonal complex.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9a868d8a-2d12-429a-9e7e-61ca131fcfb5EnglishSymplectic Elements at Oxford2014Miller, RWalker, AGodwin, HFung, RVotintseva, ABowden, RMant, DPeto, TCrook, DKnox, KBACKGROUND: Staphylococcus aureus nasal carriage increases infection risk. However, few studies have investigated S. aureus acquisition/loss over >1 year, and fewer still used molecular typing. METHODS: 1123 adults attending five Oxfordshire general practices had nasal swabs taken. 571 were re-swabbed after one month then every two months for median two years. All S. aureus isolates were spa-typed. Risk factors were collected from interviews and medical records. RESULTS: 32% carried S. aureus at recruitment (<1% MRSA). Rates of spa-type acquisition were similar in participants S. aureus positive (1.4%/month) and negative (1.8%/month, P = 0.13) at recruitment. Rates were faster in those carrying clonal complex (CC)15 (adjusted (a)P = 0.03) or CC8 (including USA300) (aP = 0.001) at recruitment versus other CCs. 157/274 (57%) participants S. aureus positive at recruitment returning ≥ 12 swabs carried S. aureus consistently, of whom 135 carried the same spa-type. CC22 (including EMRSA-15) was more prevalent in long-term than intermittent spa-type carriers (aP = 0.03). Antibiotics transiently reduced carriage, but no other modifiable risk factors were found. CONCLUSIONS: Both transient and longer-term carriage exist; however, the approximately constant rates of S. aureus gain and loss suggest that 'never' or truly 'persistent' carriage are rare. Long-term carriage varies by strain, offering new explanations for the success of certain S. aureus clones. |
| spellingShingle | Miller, R Walker, A Godwin, H Fung, R Votintseva, A Bowden, R Mant, D Peto, T Crook, D Knox, K Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: the effect of clonal complex. |
| title | Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: the effect of clonal complex. |
| title_full | Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: the effect of clonal complex. |
| title_fullStr | Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: the effect of clonal complex. |
| title_full_unstemmed | Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: the effect of clonal complex. |
| title_short | Dynamics of acquisition and loss of carriage of Staphylococcus aureus strains in the community: the effect of clonal complex. |
| title_sort | dynamics of acquisition and loss of carriage of staphylococcus aureus strains in the community the effect of clonal complex |
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