Structural basis for therapeutic inhibition of complement C5.

Structural basis for therapeutic inhibition of complement C5.

Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic potential of C5 inhibition has been demonstrated by eculizumab, one of the world's most expensive drugs. However, the mechanism of C5 activation by C5 co...

書誌詳細
主要な著者:	Jore, M, Johnson, S, Sheppard, D, Barber, N, Li, Y, Nunn, M, Elmlund, H, Lea, S
フォーマット:	Journal article
言語:	English
出版事項:	Nature Publishing Group 2016

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