Penicillin derivatives inhibit the SARS-CoV-2 main protease by reaction with its nucleophilic cysteine

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• Alkyne derivatives of SARS-CoV-2 main protease inhibitors including nirmatrelvir inhibit by reacting covalently with the nucleophilic cysteine
  gan: Brewitz, L, et al.
  Cyhoeddwyd: (2023)
• Mechanistic and inhibition studies on a nucleophilic cysteine protease and transpeptidases
  gan: Malla, TR
  Cyhoeddwyd: (2022)
• In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease
  gan: Miura, T, et al.
  Cyhoeddwyd: (2023)
• Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein
  gan: Chan, HTH, et al.
  Cyhoeddwyd: (2023)
• Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification
  gan: Brewitz, L, et al.
  Cyhoeddwyd: (2023)