The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

VCP/p97 regulates numerous cellular functions by mediating protein degradation through its segregase activity. Its key role in governing protein homoeostasis has made VCP/p97 an appealing anticancer drug target. Here, we provide evidence that VCP/p97 acts as a regulator of cellular metabolism. We fo...

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Bibliographic Details
Main Authors: Parzych, K, Saavedra-García, P, Valbuena, G, Al-Sadah, H, Robinson, M, Penfold, L, Kuzeva, D, Ruiz-Tellez, A, Loaiza, S, Holzmann, V, Caputo, V, Johnson, D, Kaiser, M, Karadimitris, A, Lam, E, Chevet, E, Feldhahn, N, Keun, H, Auner, H
Format: Journal article
Language:English
Published: Springer Nature 2019

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